Obesity Clinical Trial
Official title:
Effectiveness of MOVI Interventions on Improving Adiposity, Cognition and Subclinical Atherosclerosis by Increasing Aerobic Cardiorespiratory Fitness: MOVI-daFit
Verified date | July 2018 |
Source | University of Castilla-La Mancha |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Project which objective is to test the effectiveness of an extracurricular physical activity intervention based on high intensity interval training (MOVI-daFit!) on improving cardiorespiratory fitness (CRF), cardiometabolic risk, executive function, and academic performance.
Status | Completed |
Enrollment | 570 |
Est. completion date | June 30, 2018 |
Est. primary completion date | June 30, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 8 Years to 11 Years |
Eligibility |
Inclusion criteria: - Schools must have at least one full classrooms for both the 4th and 5th grade of primary school. - The approval of boards of governors will be necessary. - Children's parents or legal representatives will sign an informed consent to participate. - Parents will be invited to collaborate by filling in questionnaires with regard to family leisure habits, sleeping, eating and getting around town. Exclusion criteria: - Severe Spanish language learning difficulties. - Serious physical or mental disorders identified by parents or teachers that would impede participation in the programme's activities. - Children diagnoses of chronic disorders, such as heart disease, diabetes or asthma, which in the opinion of their paediatricians would prevent their participation in the programme's activities (MOVI-daFit!). |
Country | Name | City | State |
---|---|---|---|
Spain | Health and Social Research Centre, University of Castilla-La Mancha | Cuenca | |
Spain | Mairena Sánchez-López | Cuenca |
Lead Sponsor | Collaborator |
---|---|
University of Castilla-La Mancha | Carlos III Health Institute |
Spain,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | VO2 max | It will be assessed by using 20-m shuttle run test, which is validated to measure maximal aerobic capacity in children from 5 years. | One year | |
Secondary | BDNF blood determination | Biochemical determinations will be performed in order to determine Brain-derived neurotrophic factor. It is a protein that, in humans, is encoded by the BDNF gene. BDNF acts on certain neurons of the central nervous system and the peripheral nervous system, helping to support the survival of existing neurons, and encourage the growth and differentiation of new neurons and synapses. In the brain, it is active in the hippocampus, cortex, and basal forebrain—areas vital to learning, memory, and higher thinking. | One year | |
Secondary | Health-related quality of life | By using the KIDSCREEN-27 for children from 8 years. | One year | |
Secondary | Sleep behaviors and sleep problems by questionnaire | By using the Spanish version of the Children's Sleep Habits Questionnaire (CSHQ) completed by parents. Four questions will be added in order to ask about bedtime, waking up, getting up, and total number of hours of sleep. | One year | |
Secondary | Sleep quality by accelerometry | The latency, quantity, duration of sleep and the number of awakenings will also be measured by accelerometry in a subsample of 242 school children. Actigraphy (ACT) is a non-invasive method used to study sleep-wake patterns and circadian rhythms by assessing movement. The GENEActive (ActivInsights) monitor will be used, a wristwatch device that monitors activity levels for extended continuous periods. |
One year | |
Secondary | Motor skills | By using the Movement Assessment Battery for Children 2 (M-ABC 2) | One year | |
Secondary | Physical activity | In a sub-sample of 242 randomly selected school children will be measured objectively by GENEActive (ActivInsights) accelerometers during seven consecutive days (including nights), with a fixed frequency of 85.7Hz to collect raw acceleration data measured in g for each axis of motion (x, y, z). | One year | |
Secondary | Body fat% | Body fat percentage measured by Bioimpedance analysis | One year | |
Secondary | Academic achievement | Children´s mean scores on mathematics and language will be considered | One year | |
Secondary | Arterial Stiffness | Carotid intima-media thickness measurement through Sonosite Micromax ultrasound (Sonosite Inc., Bothell, Washington, USA). | One year | |
Secondary | Pulse wave velocity | Pulse wave velocity measurement through SphymgoCor System (AtCor Medical Pty Ltd Head Office, West Ryde, Australia) | One year | |
Secondary | Subclinical atherosclerosis | Reactive Hyperemia index measurement through ENDO- PAT (Moerland et al. Int J Vasc Med, 2012; 17; 682-86) | One year | |
Secondary | Executive function | Executive function will be measured by standardized tests using the NIH toolbox | One year | |
Secondary | Glucose profile | Glucose (mg/dl) level will be determined by using a system Cobas 8000 of Roche Diagnostics | One year | |
Secondary | Lipid profile | Apolipoproteins (mg/dl) level will be determined by using a system Cobas 8000 of Roche Diagnostics. | One year | |
Secondary | Insulin profile | Insulin (µU/L) level will be determined by using the Architect platform of Abbott ® | One year | |
Secondary | Ultrasensitive protein profile | C-reactive protein ultrasensitive (mg/l) level will be determined by using a system Cobas 8000 of Roche Diagnostics | One year |
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