Obesity Clinical Trial
Official title:
Effects of Change in Insulin Resistance and Systemic Inflammation After Bariatric Surgery on Brain Neurochemistry, Neuroinflammation and Cognitive Function
Verified date | June 2021 |
Source | University of Minnesota |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Obesity is associated with alterations in brain structure and cognitive impairment and is a risk factor for Alzheimer's disease and vascular dementia. The mechanisms underlying obesity related decline in cognitive function are not fully understood. The long-term goal of this project is to understand how obesity affects cognitive function, with the aim to develop new ways to prevent and treat obesity related cognitive decline
Status | Completed |
Enrollment | 29 |
Est. completion date | February 11, 2020 |
Est. primary completion date | February 11, 2020 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 30 Years to 50 Years |
Eligibility | Inclusion Criteria: Obese Group - Undergoing VSG-type bariatric surgery - BMI > 30 - Current weight less than 400 lbs Non-Obese Group - Age 30-50 - BMI < 25 Exclusion Criteria: Both Groups - History of type 1 or type 2 diabetes - History of stroke - History of epilepsy - History of Neurosurgical procedures - Past or current history of severe psychiatric illness - Pass or current history of alcohol or substance abuse - Absence of metallic substances in body or ability to remove before imaging procedure - History of claustrophobia or known inability to tolerate MRI - Inability to consent |
Country | Name | City | State |
---|---|---|---|
United States | Clinical and Translational Science Institute and Center for Magnetic Resonance Research, University of Minnesota | Minneapolis | Minnesota |
Lead Sponsor | Collaborator |
---|---|
University of Minnesota |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change insulin resistance and inflammatory markers | Change in insulin resistance and blood inflammatory markers from baseline (before surgery) and at 6 months post surgery | at baseline (before surgery) and 6 months post surgery | |
Secondary | change in neurocognitive function testing | changes in neurocognitive function testing from baseline (before surgery) and at 6 months post surgery | at baseline (before surgery) and 6 months post surgery |
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