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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT03215888
Other study ID # MED-2017-25812
Secondary ID
Status Completed
Phase
First received
Last updated
Start date November 1, 2017
Est. completion date February 11, 2020

Study information

Verified date June 2021
Source University of Minnesota
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Obesity is associated with alterations in brain structure and cognitive impairment and is a risk factor for Alzheimer's disease and vascular dementia. The mechanisms underlying obesity related decline in cognitive function are not fully understood. The long-term goal of this project is to understand how obesity affects cognitive function, with the aim to develop new ways to prevent and treat obesity related cognitive decline


Description:

A growing body of evidence suggests that obesity is associated with alterations in brain structure and cognitive impairment. Mid-life obesity is a risk factor for Alzheimer's disease and vascular dementia. The mechanisms underlying obesity related decline in cognitive function are not fully understood. The long-term goal of this research is to identify how obesity, insulin resistance (IR), and their treatment impact brain structure and function. The investigators propose that IR and obesity related inflammation are two modifiable factors that affect neuronal integrity and lead to cognitive dysfunction. In this proposal, investigators will test two hypotheses: 1) among obese patients planning to undergo bariatric surgery (specifically vertical sleeve gastrectomy), baseline IR and systemic and brain markers of inflammation will inversely correlate with performance on cognitive testing and correlate with abnormalities in brain structure and 2) following bariatric surgery subjects who experience the greatest reduction in IR and obesity related inflammation will have the greatest improvement in cognitive function and brain structure. To address these hypotheses, investigators will use a comprehensive battery of tests to evaluate cognition and state of the art magnetic resonance imaging (MRI) techniques to assess brain structure and neurochemistry before and six months after bariatric surgery.


Recruitment information / eligibility

Status Completed
Enrollment 29
Est. completion date February 11, 2020
Est. primary completion date February 11, 2020
Accepts healthy volunteers No
Gender All
Age group 30 Years to 50 Years
Eligibility Inclusion Criteria: Obese Group - Undergoing VSG-type bariatric surgery - BMI > 30 - Current weight less than 400 lbs Non-Obese Group - Age 30-50 - BMI < 25 Exclusion Criteria: Both Groups - History of type 1 or type 2 diabetes - History of stroke - History of epilepsy - History of Neurosurgical procedures - Past or current history of severe psychiatric illness - Pass or current history of alcohol or substance abuse - Absence of metallic substances in body or ability to remove before imaging procedure - History of claustrophobia or known inability to tolerate MRI - Inability to consent

Study Design


Intervention

Procedure:
bariatric surgery
Obese patients will undergo brain imaging, neurocognitive function testing and measurement of insulin resistance and inflammatory markers pre- and post bariatric surgery

Locations

Country Name City State
United States Clinical and Translational Science Institute and Center for Magnetic Resonance Research, University of Minnesota Minneapolis Minnesota

Sponsors (1)

Lead Sponsor Collaborator
University of Minnesota

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary Change insulin resistance and inflammatory markers Change in insulin resistance and blood inflammatory markers from baseline (before surgery) and at 6 months post surgery at baseline (before surgery) and 6 months post surgery
Secondary change in neurocognitive function testing changes in neurocognitive function testing from baseline (before surgery) and at 6 months post surgery at baseline (before surgery) and 6 months post surgery
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