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Carnitine and Liver Mitochondria Fatty Acid Processing

Obesity Clinical Trial

Official title:
Effects of Carnitine Supplementation on Liver Mitochondria Fatty Acid Processing

Clinical Trial Summary

This double-blind, placebo-controlled randomized trial will assess whether 14 days of oral carnitine supplementation modifies mitochondrial fatty acid processing in healthy young adults.

Clinical Trial Description

This project will use stable isotope techniques and magnetic resonance spectroscopy (MRS) to take a first step toward clarifying how the benefit of oral carnitine supplementation depends on basal mitochondrial fatty acid processing (MFAP) and MFAP modification, with a specific focus on the liver. Approximately 24 healthy young individuals will be enrolled, with 20 expected to complete. Before and after 14 days of oral carnitine supplementation or placebo, MFAP will be measured using measures of acetyl-carnitine concentration (from long-TE proton MRS) and de novo lipogenesis (DNL, from analysis of blood metabolites following 13C-labeled acetate infusion and high-fructose drink challenge). The MFAP measures will be collected before and after loading participants with a high-fructose drink. Fructose is solely metabolized by the liver. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03193125
Study type Interventional
Source Pennington Biomedical Research Center
Contact
Status Completed
Phase N/A
Start date May 15, 2017
Completion date May 11, 2018
View Details
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