Obesity Clinical Trial
Official title:
Human Brown Adipose Tissue Histological and Mitochondrial Respiratory Analysis
This study is focused on measuring mitochondrial activity of human brown adipose tissue. During surgery, adipose tissue biopsies from white and brown adipose tissue will be collected from the deep neck area. These biopsies will be used to examine mitochondrial function via histological analysis, biochemical analysis and in vitro experiments based on precursor cells present in the biopsies.
Status | Recruiting |
Enrollment | 180 |
Est. completion date | October 10, 2021 |
Est. primary completion date | October 10, 2021 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 65 Years |
Eligibility |
Inclusion Criteria: - Indication for surgery in the supraclavicular and neck region (more specific patients diagnosed with hyperparathyroidism, struma, benign thyroid gland tumours, implantation of a vagal neurostimulator for epilepsia and cervical neurologic disorders) - In the thyroid gland group, euthyroid function Exclusion Criteria: - Pre-operatively diagnosed malign tumour - Patients undergoing acute surgery because of critical illness |
Country | Name | City | State |
---|---|---|---|
Netherlands | Maastricht University Medical Center / University of Maastricht | Maastricht |
Lead Sponsor | Collaborator |
---|---|
Maastricht University Medical Center | Ministry of Education, Culture and Science |
Netherlands,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Mitochondrial respiration in human brown | Measure of mitochondrial respiration in human brown adipose tissue biopsies and measure mitochondrial respiration in cells derived from human brown adipose tissue biopsies. With high resolution respirometry , oxygen consumption in mitochondria will be determined using different substrates that stimulate mitochondrial activity including norepinephrine which is a natural agonist to increase mitochondrial activity in brown adipose tissue. During these experiments mitochondrial complex activity can be inhibited using specific inhibitors. | 8 weeks | |
Secondary | Characterise human brown adipose tissue | Perform histological analysis and biochemical analysis in brown adipose tissue biopsies and compare to skeletal muscle. Via qPCR analysis, western blotting and immunfluorescence we will examine UCP1 expression in BAT. | 8 weeks |
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