Obesity Clinical Trial
Official title:
Immunosuppression and Diet: the Role of Inflammation in the Adipose Tissue Remodeling After Liver Transplantation
The main goal of this project is to evaluate the effect of immunosuppression in the weight loss and in the metabolic status of patients after liver transplantation. It is also the purpose of this project to investigate why patients become overweight and obese after liver transplantation.
Overweight and obese post-liver transplantation patients will receive a diet to promote
weight loss during 6 months. The control group (overweight and obese subjects) will be
submitted to the same protocol:
The participants will be interviewed at baseline and after 30, 60, 90 and 180 days from
baseline. The following measures will be assessed: body composition (fat body% and free fat
body%), anthropometric measures (height, weight, body mass index, waist circumference and
abdominal circumference), blood pressure, basal metabolic rate, behavioral symptoms and
peripheral biomarkers in the serum. Behavioral symptoms will be assessed using the following
self-reported questionnaires: Beck Depression Inventory (depression symptoms), Beck Anxiety
Inventory (anxiety symptoms), Medical Outcomes Study 36 - Item Short - Form Health Survey
(quality of life) and Perceived Stress Scale (stress).
Enrolled participants will receive a restrictive diet calculated based on individual
requirements aiming the loss of around 5%-10% of weight/ 6 months of intervention.
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