Obesity Clinical Trial
Official title:
Exercise Capacity and Dyspnea in Obese Patients With Metabolic Syndrome: Effects of Weight Loss
Dyspnea is a common complaint in obese patients. The mechanisms behind this dyspnea and the
effects of weight loss on dyspnea are not completely understood. The objectives of this study
were to examine the relationships between exercise parameters and dyspnea in obesity and
assess the effects of weight loss.
The investigators compared pulmonary function, exercise performance and dyspnea in 34
patients with abdominal obesity and metabolic syndrome (MS) against 34 age and sex-matched
controls. The study also assessed within-group changes in physiology and symptoms in a subset
of patients following participation in a weight management program.
Because obesity is a heterogeneous condition, with variable genetic associations,
co-morbidities and distributions of adipose tissue, the study focused on patients with
abdominal obesity who met diagnostic criteria for metabolic syndrome.
The study has two parts: first, the investigators compared dyspnea, pulmonary function and exercise measurements between obese patients and control subjects with normal weight; then, the investigators assessed the effects of medical weight loss in the obese group on these parameters. Baseline dyspnea was assessed using the baseline dyspnea index.The effect of weight loss on dyspnea was assessed using the transitional dyspnea index. The main physiologic measurement of interest was the inspiratory capacity (L, measured at rest and during exercise). ;
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