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Longitudinal Assessment of Bariatric Surgery Sub-Study — LABS-3  

Obesity Clinical Trial

Official title:
Longitudinal Assessment of Bariatric Surgery Sub-Study: A Prospective, Longitudinal Cohort Study of the Mechanisms for Improvement of Type 2 Diabetes Following Bariatric Surgery (LABS-3 DIABETES)

Clinical Trial Summary

The goal of this project is to examine the physical mechanisms that contribute to improvements of glucose tolerance in type 2 diabetes mellitus (DM) following certain types of bariatric surgery.

Clinical Trial Description

The goal of this project is to examine the physiological mechanisms that contribute to improvements of glucose homeostasis in type 2 diabetes mellitus (DM) following gastric bypass Roux-en-Y bariatric surgery (GBP). The central hypotheses are: 1) that surgical changes in the anatomy of nutrient absorption achieved by GBP change incretin hormone secretion which in turn improves pancreatic islet function; and 2) that improvement in insulin secretion induced by the changes in incretin function, together with improvement in insulin resistance induced by weight loss, normalize glucose homeostasis in type 2 DM. Funds are not available to pay for the surgery for patients, only to address research questions. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02985853
Study type Observational
Source Oregon Health and Science University
Contact
Status Active, not recruiting
Phase
Start date March 2008
Completion date September 2024
View Details
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