Obesity Clinical Trial
Official title:
Effects of Different Metabolic States and Surgical Models on Glucose Metabolism and Secretion of Ileal L-cell Peptides
The HIPER-1 study is a single centre cross sectional study in which a total of 240 participants (in different metabolic states and surgical models) will receive an Oral Mixed Meal Tolerance Test (OMTT). At baseline and after 30, 60 and 120 minutes the PYY levels, GLP-1 levels, glucose and insulin sensitivity will be measured. The primary endpoint of the study will be the area under the GLP-1 and Peptide - YY curves and insulin sensitivity following the OMTT.
Obesity and type 2 diabetes mellitus (T2DM) are increasing worldwide, thus reaching pandemic
proportions. Diet, exercise and medication remain the cornerstones of type 2 diabetes
mellitus treatment. But, apart from studies demonstrating promising results in some of the
developed countries; the long-term success rates of lifestyle and drug modifications are
disappointing. In cases where classic strategies proved to be inadequate, broad type of
gastrointestinal (GI) surgery methods offer new alternatives to treat obesity and T2DM. The
variable levels of incretin stimulation (especially GLP-1) and improved glycaemic control in
those with diabetes have been shown following various bariatric techniques.
Therefore, investigators aimed to analyze the levels of GLP-1 and Peptide YY hormones
together with indices of insulin sensitivity in participants with various health conditions
and in participants who underwent different surgical options including sleeve gastrectomy,
minigastric bypass, sleeve gastrectomy with ileal transposition and sleeve gastrectomy with
transit bipartition.
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Observational Model: Cohort, Time Perspective: Prospective
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