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Exercise for Healthy Aging: The Impact of HIV and Aging on Physical Function and the Somatopause

Obesity Clinical Trial

Official title:
Exercise for Healthy Aging: The Impact of HIV and Aging on Physical Function and the Somatopause

Clinical Trial Summary

The primary objective of this proposal is to compare a moderate or high intensity exercise intervention to improve physical function in persons aging with Human Immunodeficiency Virus (HIV).

Clinical Trial Description

The primary objective of this proposal is to compare a moderate or high intensity exercise intervention to improve physical function in persons aging with HIV. Both HIV-infected and HIV-uninfected older adults will be assigned to a moderate intensity cardiovascular and resistance training intervention for 12 weeks, and then randomized to either continue moderate intensity exercise, or increase to high intensity exercise for an additional 12 weeks. The primary outcome is the impact of exercise on physical function, as measured by the overall score of a modified Short Physical Performance Battery (mSPPB) and the chair rise time from the mSPPB. The secondary outcomes include changes in insulin-like growth factor-1 (systemic and local) and inflammation (interleukin-6 (IL-6), soluble tumor necrosis factor receptors 1 and 2 (sTNFR-1 and sTNFR-2)). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02404792
Study type Interventional
Source University of Colorado, Denver
Contact
Status Completed
Phase N/A
Start date April 2015
Completion date March 1, 2018
View Details
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