Obesity Clinical Trial
Official title:
Treatment of Morbidly Obese Adolescent With a Duodena-jejunal Liner - a Study on Efficacy and Pathophysiologic Mechanisms
Obesity and its complications have a significant effect on morbidity and mortality in these
subjects. Especially at risk are subjects with extremely increased BMI (above 99th percentile
for age and gender in adolescents). In these subjects classical treatment with diet and
cognitive therapy has a limited effect. Bariatric procedures, at the moment, are the only
feasible therapeutic possibility.
Bariatric procedures are based on several principles; restrictive, malabsorptive and
combined. They can be surgical or endoscopic. The later are used in subjects that do not
qualify for surgical procedures that decline them or are used before a planed definite
bariatric procedure.
Duodena-jejunal liner (DJL) is an endoscopic tool, that is efficiently and safely used to
decrease body weight and ameliorated obesity complications, especially those associated with
diabetic state.
Aims of the study are:
- To determine (short and long-term) efficacy of DJL in decreasing body weight in
adolescents.
- To determine (short and long-term) efficacy of DJL in ameliorating complications of
morbid obesity - abnormal glucose metabolism, dislipidemia, altered adipokine secretion
pattern, altered secretion pattern of gastrointestinal hormones in adolescents.
- To visualize functional alternations in the selected central nervous system regions
associated with appetite regulation upon insertion of DJL.
- To evaluate psychological outcomes; change in emotional and behaviour problems, in body
image, in eating disorder symptoms.
n/a
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