Liver and Fat Regulation in Overweight Adolescent Girls — APPLE  

Obesity Clinical Trial

Official title: Assessment of Hepatic Glucose and Fat Regulation in Overweight Adolescent Girls

Status Completed

Clinical Trial Summary

Women with polycystic ovarian syndrome (PCOS) have increased rates of hepatic steatosis compared to weight similar women with regular menses. It is unclear if this is related to high testosterone or insulin resistance. The investigators will assess hepatic glucose release, rates of lipolysis and hepatic de novo lipogenesis in the fasted and postprandial state to determine if alterations in the processes contribute to hepatic steatosis. Participants will be overweight, sedentary girls with or without PCOS. Those with PCOS will either be medication naive, or must be taking metformin or combined oral contraceptives (COCPs) for a period of at least 6 months prior to study procedures.

Clinical Trial Description

Hepatic glucose release will be assessed with a stable isotope glycerol tracer, lipolysis with a glycerol tracer, and hepatic de novo lipogenesis with an acetate tracer. Data will be collected fasting and after a glucose challenge. The degree of hepatic steatosis and abdominal fat partitioning will be assessed with Magnetic Resonance Imaging (MRI), and total body composition with Dual-energy X-ray absorptiometry (DEXA). ;

Related Conditions & MeSH terms

• Fatty Liver
• Hepatic Steatosis
• Obesity
• Overweight
• Polycystic Ovarian Syndrome
• Polycystic Ovary Syndrome

• NCT number: NCT02157974
• Study type: Interventional
• Source: University of Colorado, Denver
• Status: Completed
• Phase: Phase 2/Phase 3
• Start date: August 2014
• Completion date: December 2022