Can Intermittent Fasting Mimic the Metabolic and Cardiovascular and Anti-aging Effects of Calorie Restriction?

Obesity Clinical Trial

— IF  

Official title:

Can Intermittent Fasting Mimic the Metabolic and Cardiovascular and Anti-aging Effects of Calorie Restriction?

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01964118
• Other study ID #: 201303081
• Status: Completed
• Phase: N/A
• Start date: July 2013
• Est. completion date: September 2016

Study information

• Verified date: May 2021
• Source: Washington University School of Medicine
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of Intermittent Fasting study is to investigate whether intermittent fasting could decrease the chronic inflammation levels in overweight/obese people.

Description:

The primary objective of this study is to determine whether or not IF reduces the level of chronic inflammation as evidenced by a decrease in high sensitive C-reactive protein (hsCRP), as the main outcome measure

Recruitment information / eligibility

• Status: Completed
• Enrollment: 50
• Est. completion date: September 2016
• Est. primary completion date: September 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 30 Years to 65 Years

Eligibility

Inclusion Criteria:

• The participants in this study will be 50 men and women in the 30 to 65 year age range, who have a BMI in the high normal to moderately obese range (i.e. 24 to 35 kg/m2),

• Participants who are eating usual US diets and are sedentary to moderately active (i.e. not exercise trained).

Exclusion Criteria:

• History of any chronic disease process that could interfere with interpretation of results

• Smoking, pregnancy, alcoholism, psychiatric problems, life situations that would interfere with study participation and compliance.

Related Conditions & MeSH terms

• Obesity
• Overweight

Intervention

Other:
• Intermittent Fasting group
Intermittent fasting for 12 months
• control group
usual diet for 6 months and intermittent fasting for other 6 months

Locations

Country	Name	City	State
United States	Washington University School of Medicine	Saint Louis	Missouri

Sponsors (1)

Lead Sponsor	Collaborator
Washington University School of Medicine

Country where clinical trial is conducted

United States, 

References & Publications (1)

Goodrick CL, Ingram DK, Reynolds MA, Freeman JR, Cider NL. Effects of intermittent feeding upon growth and life span in rats. Gerontology. 1982;28(4):233-41. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in HSCRP ( high sensitivity C-reactive protein) at 6 and 12 months	HSCRP would be measured in mg/L	Every 6 months- baseline, 6 month and 12 month