Pilot Study for Noninvasive Spectroscopic Detection of Adipose Tissue Inflammation in Obesity

Obesity Clinical Trial

Official title:

Pilot Study for Noninvasive Spectroscopic Detection of Adipose Tissue Inflammation in Obesity

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01900366
• Other study ID #: JAL-0809
• Status: Completed
• Phase: N/A
• First received: July 11, 2013
• Last updated: September 16, 2016
• Start date: August 2013
• Est. completion date: August 2016

Study information

• Verified date: September 2016
• Source: Rockefeller University
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

This study will test the potential of two techniques using light properties of adipose tissue to diagnose crown-like structures and inflammation to be compared with pathologic examination of adipose tissue biopsies from ongoing clinical studies.

Description:

Adipose tissue (fat) inflammation is emerging as an important harbinger of disease development including Type 2 diabetes, heart disease and potentially cancer. The hallmark feature of adipose tissue inflammation is the crown-like structure, a dying fat cell surrounded by immune cells attempting to clear the damage. Current methods for detecting adipose tissue inflammation rely on invasive procedures such as fat biopsies. We propose developing methods that use the light reflection properties of inflamed adipose tissue as a potential non-invasive method to detect adipose tissue inflammation.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 14
• Est. completion date: August 2016
• Est. primary completion date: August 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

-Subjects currently enrolled in a current Rockefeller University study who will be undergoing adipose tissue biopsies as part of the study protocol

Exclusion Criteria:

-History of any skin disease

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

• Inflammation
• Obesity

Intervention

Procedure:
• Fat Biopsy
Fat biopsy

Locations

Country	Name	City	State
United States	The Rockefeller University	New York	New York

Sponsors (2)

Lead Sponsor	Collaborator
Rockefeller University	Weill Medical College of Cornell University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Classification of adipose tissue as healthy or inflamed by Raman Spectroscopy	Classification of adipose tissue as healthy or inflamed by Raman Spectroscopy	1 day	No
Secondary	Steady state oxygenation at the site of tissue biopsy by Diffuse Reflectance Spectroscopy	Steady state oxygenation at the site of tissue biopsy by Diffuse Reflectance Spectroscopy	1 day	No