Obesity Clinical Trial
Official title:
Effect Of Concord Grape Juice On Endothelial Function In Obese And Overweight Individuals Over Age 50
The study will compare Concord grape juice to a beverage that contains no grape flavonoids,
but has a similar appearance and taste (placebo juice). A total of 60 overweight and obese
participants over age 50 will be enrolled. Each participant will drink each beverage for 4
weeks with a 2-week rest period between two beverage consumption periods. The order of
beverages (grape juice first or placebo juice first) will be randomized. The investigators
will use ultrasound to measure brachial artery flow-mediated dilation, a measure of
endothelial vasodilator function. The investigators will also collect blood samples to
further assess the cardiovascular effects of grape juice.
The aim of the study is to determine whether Concord grape juice improves endothelial
function in patients at risk who do not have cardiovascular disease and may provide
information that would guide dietary recommendations. The results may also be used by the
sponsor to substantiate claims and labeling of their product.
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