A Study of the Effects of Fish Protein Intake on Glucose Regulation in Overweight and Obese Adults.

Obesity Clinical Trial

— FISK3  

Official title:

A 8 wk Study to Compare the Effects of Proteins Various Fish Species (Salmon, Herring, Cod) and Milk on Glucose Regulation in Overweight and Obese Adults.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01641055
• Other study ID #: 2011/572
• Status: Completed
• Phase: N/A
• Start date: July 2012
• Est. completion date: November 2012

Study information

• Verified date: March 2022
• Source: University of Bergen
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to compare the possible health benefits of intake of proteins from salmon, herring, cod and milk on glucose tolerance in overweight and obese adults. Overweight and obese subjects often have reduced glucose tolerance, and previous findings from a study on cod proteins suggested that glucose tolerance was improved.

Description:

Participants receive 2.5g protein per day for 8 weeks as tablets.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 93
• Est. completion date: November 2012
• Est. primary completion date: November 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 69 Years

Eligibility

Inclusion Criteria:

• BMI above 27 kg/m2

• healthy

Exclusion Criteria:

• fasting blood glucose above 7 mM

• medication that affects blood glucose, lipids and inflammatory status

• pregnancy or breastfeeding

• allergies to fish or milk

• intentional weight loss and large fluctuation in body weight

• a high consumption of fish

• an extreme diet

• use of fish oil, n-3 or multivitamin supplements

Related Conditions & MeSH terms

• Obesity
• Overweight

Intervention

Dietary Supplement:
• Salmon protein hydrolysate
2.5g salmon protein hydrolysate per day for 8wk.
• Herring protein hydrolysate
2.5g herring protein hydrolysate per day for 8wk.
• Cod protein
2.5g cod protein per day for 8wk.
• Milk protein
2.5g milk protein per day for 8wk.

Locations

Country	Name	City	State
Norway	Institute of Medicine, University of Bergen	Bergen

Sponsors (3)

Lead Sponsor	Collaborator
University of Bergen	BlueProtein, NutriMar

Country where clinical trial is conducted

Norway, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Glucose regulation	Glucose will be measured in fasting and postprandial samples	8 weeks
Secondary	Changes in serum insulin, insulin C-peptide, non-esterified fatty acids, lipids, adiponectin, leptin and fatty acid composition		8 weeks
Secondary	Changes in serum and urine concentrations of amino acids and their metabolites		8 weeks
Secondary	Changes in serum concentrations of vitamins		8 weeks
Secondary	Comparisons of metabolites and co-factors involved in one-carbon metabolism in serum and urine	Concentrations of relevant metabolites and co-factors were measured in serum and urine	8 weeks