Obesity Clinical Trial
Official title:
Plasma Adiponectin Level and Sleep Structures in Children With Prader-Willi Syndrome
Context: Adiponectin is an adipose tissue-derived hormone with an insulin sensitizing
effect, and has been related to obstructive sleep apnea syndrome. In addition, children with
Prader-Willi syndrome (PWS) suffer from excessive daytime sleepiness and the abnormality of
rapid eye movement (REM) sleep.
Objective: To determine if the sleep stages are related to the plasma levels of adiponectin,
resistin, and RBP4 (retinol binding protein-4), and whether these relationships are
influenced by age, obesity and insulin resistance.
This comparative study was carried out in 28 PWS children and 18 controls. The enrolled PWS children were volunteers out of a pool of approximately 100 PWS children followed at Samsung Medical Center [median age 8.0 years, interquartile range (7.0-10.5 years), BMI: median 24.2 kg/m2 (23.0-27.5 kg/m2)] and 18 obese healthy children [median age 9.0 years interquartile range (7.0-11.0 years), BMI: median 24.2 kg/m2 interquartile range (23.1-27.6 kg/m2)]. ;
Observational Model: Case Control, Time Perspective: Prospective
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