Effects of Different Coffee Amounts on Energy Intake, Appetite, Glucose Metabolism and Inflammatory Markers

Obesity Clinical Trial

Official title:

The Effect of Different Amounts of Coffee on Dietary Intake, Appetite-related Feeling, Appetite Hormones, Glucose Metabolism and Inflammatory Markers of Normal Weight and Overweight/Obese Individuals

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01495754
• Other study ID #: CofSt3
• Status: Completed
• Phase: N/A
• First received: December 16, 2011
• Last updated: December 19, 2011
• Start date: January 2011
• Est. completion date: June 2011

Study information

• Verified date: December 2011
• Source: Harokopio University
• Contact: n/a
• Is FDA regulated: No
• Health authority: Greece: Ethics Committee
• Study type: Interventional

Clinical Trial Summary

The purpose of the study is to investigate whether different doses of caffeinated coffee consumption has acute effects on subjective appetite feelings, energy intake and biochemical markers related to appetite, inflammation and glucose metabolism compared to water consumption in normal weight and overweight/obese participants.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 33
• Est. completion date: June 2011
• Est. primary completion date: June 2011
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• apparently healthy

• habitual coffee drinkers (>= 1cup of coffee/day)

Exclusion Criteria:

• smokers

• restrained eaters (as this was evaluated using the Dutch Eating Behaviour Questionnaire)

• those who reported slimming or any other dietary regime

• athletes

• participants with a known diagnosis of either hypertension, diabetes, impaired glucose tolerance or a fasting blood glucose concentration above 125 mg/dl

• subjects on medication for hypertension or on medication known to alter glucose metabolism

• subjects who were on medication that may have an impact on appetite and sensory functioning or who reported a metabolic or

• endocrine disease,

• gastrointestinal disorders,

• a history of medical or surgical events that may have affected the study outcomes

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Inflammation
• Obesity

Intervention

Other:
• coffee
Comparison of different amounts of coffee

Locations

Country	Name	City	State
Greece	Metabolic Unit of the Department of Nutrition and Dietetics, Harokopio University	Athens

Sponsors (1)

Lead Sponsor	Collaborator
Harokopio University

Country where clinical trial is conducted

Greece, 

References & Publications (1)

Gavrieli A, Yannakoulia M, Fragopoulou E, Margaritopoulos D, Chamberland JP, Kaisari P, Kavouras SA, Mantzoros CS. Caffeinated coffee does not acutely affect energy intake, appetite, or inflammation but prevents serum cortisol concentrations from falling in healthy men. J Nutr. 2011 Apr 1;141(4):703-7. doi: 10.3945/jn.110.137323. Epub 2011 Feb 23. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	energy intake ad libitum		180 min after breakfast/drink consumption	No
Primary	total energy intake		One day	No
Primary	appetite feelings		fasting (-15 min)	No
Primary	appetite feelings		immediately after breakfast/drink consumption (0 min)	No
Primary	appetite feelings		15 min after breakfast/drink consumption	No
Primary	appetite feelings		30 min after breakfast/drink consumption	No
Primary	appetite feelings		60 min after breakfast/drink consumption	No
Primary	appetite feelings		90 min after breakfast/drink consumption	No
Primary	appetite feelings		120 min after breakfast/drink consumption	No
Primary	appetite feelings		150 min after breakfast/drink consumption	No
Primary	appetite feelings		180 min after breakfast/drink consumption	No
Primary	appetite hormones		fasting (-15 min)	No
Primary	appetite hormones		immediately after breakfast/drink consumption (0 min)	No
Primary	appetite hormones		15 min after breakfast/drink consumption	No
Primary	appetite hormones		30 min after breakfast/drink consumption	No
Primary	appetite hormones		60 min after breakfast/drink consumption	No
Primary	appetite hormones		90 min after breakfast/drink consumption	No
Primary	appetite hormones		120 min after breakfast/drink consumption	No
Primary	appetite hormones		150 min after breakfast/drink consumption	No
Primary	appetite hormones		180 min after breakfast/drink consumption	No
Primary	markers of inflammation		fasting (-15 min)	No
Primary	markers of inflammation		immediately after breakfast/drink consumption (0 min)	No
Primary	markers of inflammation		15 min after breakfast/drink consumption	No
Primary	markers of inflammation		30 min after breakfast/drink consumption	No
Primary	markers of inflammation		60 min after breakfast/drink consumption	No
Primary	markers of inflammation		90 min after breakfast/drink consumption	No
Primary	markers of inflammation		120 min after breakfast/drink consumption	No
Primary	markers of inflammation		150 min after breakfast/drink consumption	No
Primary	markers of inflammation		180 min after breakfast/drink consumption	No
Primary	markers of glucose metabolism		fasting (-15 min)	No
Primary	markers of glucose metabolism		immediately after breakfast/drink consumption (0 min)	No
Primary	markers of glucose metabolism		15 min after breakfast/drink consumption	No
Primary	markers of glucose metabolism		30 min after breakfast/drink consumption	No
Primary	markers of glucose metabolism		60 min after breakfast/drink consumption	No
Primary	markers of glucose metabolism		90 min after breakfast/drink consumption	No
Primary	markers of glucose metabolism		120 min after breakfast/drink consumption	No
Primary	markers of glucose metabolism		150 min after breakfast/drink consumption	No
Primary	markers of glucose metabolism		180 min after breakfast/drink consumption	No
Secondary	% carbohydrates ad libitum		180 min after breakfast/drink consumption	No
Secondary	% carbohydrates total day		One day	No
Secondary	% protein ad libitum		180 min after breakfast/drink consumption	No
Secondary	% protein total day		One day	No
Secondary	% fat		180 min after breakfast/drink consumption	No
Secondary	% fat total day		One day	No