Effects of Exercise-intensity on Physiological Adaptations in Overweight and Obese

Obesity Clinical Trial

— TRENO  

Official title:

Effects of Exercise-intensity on Physiological Adaptations in Overweight and Obese

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01453972
• Other study ID #: TRENO
• Status: Completed
• Phase: N/A
• First received: October 10, 2011
• Last updated: August 1, 2016
• Start date: October 2011
• Est. completion date: December 2012

Study information

• Verified date: August 2016
• Source: Norwegian University of Science and Technology
• Contact: n/a
• Is FDA regulated: No
• Health authority: Norway: Regional Ethics Commitee
• Study type: Interventional

Clinical Trial Summary

The main purpose of our study is to examine the physiological adaptations in oxygen transport chain for high-intensity exercise and moderate exercise in overweight and obese humans. The main goals are:

1. To investigate the most effective short-and long-interval training in terms of VO2max, pulmonary diffusion, cardiac output, endothelial function and mitochondrial function.

2. How these physiological adaptations affect the aerobic endurance and performance, and how this training can reduce the risk of cardiovascular diseases related to overweight and obesity.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: December 2012
• Est. primary completion date: February 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• BMI > 25

Exclusion Criteria:

• Exclusion criteria will be cardiovascular disease or another disease that is not consistent with high physical activity. Subjects should not have exercised regularly before the study.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Obesity
• Overweight

Intervention

Behavioral:
• Long distanse moderate training
Moderate exercise
• Long interval training
High-intensity exercise, long duration
• Short interval training
High intensity exercise, short duration

Locations

Country	Name	City	State
Norway	Medical Faculty, Norwegian University of Science and Technology	Trondheim	Sør-Trøndelag

Sponsors (1)

Lead Sponsor	Collaborator
Norwegian University of Science and Technology

Country where clinical trial is conducted

Norway, 

References & Publications (1)

Bækkerud FH, Solberg F, Leinan IM, Wisløff U, Karlsen T, Rognmo Ø. Comparison of Three Popular Exercise Modalities on V?O2max in Overweight and Obese. Med Sci Sports Exerc. 2016 Mar;48(3):491-8. doi: 10.1249/MSS.0000000000000777. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Maximal oxygen uptake	Change in maximal oxygen uptake will be measured after six weeks of various exercise training and related to changes in blood volume, cardiac function, endothelial function and mitochondrial function.	6 weeks	No