Obesity Clinical Trial
Official title:
The Oral Fructose Load Test and Inflammation, Lipid Metabolism, Blood Pressure and Organ Damage in Patients With Obesity, Chronic Kidney Disease With Comparison With Healthy Controls.
Fructose intake from added sugars has increased dramatically over the last century and has
recently been implicated as potential contributor to metabolic syndrome, obesity,
hypertension, inflammation and kidney disease. Fructose differs from the other sugars
because, uric acid is generated during its metabolism. Serum uric acid levels have been
found to correlate with the intake of fructose and added sugars. In turn, an elevated serum
uric acid has also been shown to be associated with increased risk for cardiovascular and
metabolic diseases. On the other hand complexity of fructose metabolism in each individuals
results of the various magnitude of hyperuricemia induced by fructose intake. The magnitude
of uric acid production in each patient may reflect individual predisposition to endogenous
urate production in a face of relatively normal fasting uric acid concentration. Therefore
the oral fructose tolerance test might reveal an occult purine disturbances which plays
casual role in either metabolic disturbances or organ damage.
The aim of this study is to see whether is a relationship between fructose induced
hyperuricemia and metabolic disturbances , inflammatory state and organ damage in obese and
various stages CKD patients.
Status | Not yet recruiting |
Enrollment | 70 |
Est. completion date | |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years to 65 Years |
Eligibility |
Inclusion Criteria: - Group I Patients with BMI> 30 and metabolic syndrome ( ATP III). Patient with BMI> 30 without metabolic syndrome. Normal healthy control- healthy persons( without renal disease, cardiovascular diseases, diabetes mellitus, BMI < 25;normotensives ). Group II Patients with CKD stage III (GFR 30-59 ml/min/1,73 m2) and uric acid < 7 mg/dl. - without diabetes mellitus proteinuria < 3,5 g/24 h without immunosuppressives agents, ACEi, ARB, allopurinol treatment well controlled hypertension ( < 140/90 mmHg) Patients with CKD stage III(GFR 30-59 ml/min/1,73 m2) and uric acid > 7 mg/dl - without diabetes mellitus proteinuria < 3,5 g/24 h without immunosuppressive agents, ACEi, ARB, allopurinol treatment well controlled hypertension ( < 140/90 mmHg) Patient with asymptomatic hyperuricemia, uric acid > 7 mg/dl with normal renal function Hemodialysis patients. - CKD: nondiabetic nephropathy - duration hemodialysis 3-48 months - Hb-11-13 g/dl - well controlled hypertension ( < 140/90 mmHg) - without ACEi, ARB, allopurinol treatment - residual diuresis will be estimated for last 48 hours-between mid and next dialysis Exclusion Criteria: - immunosuppressive agents, ACEi, ARB, allopurinol treatment - diabetes mellitus - not well controlled hypertension ( > 140/90 mmHg) - proteinuria > 3,5 g/24 h |
Observational Model: Case Control, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Collegium Medicum w Bydgoszczy | University of Colorado, Denver |
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