Obesity Clinical Trial
Official title:
Optimizing the Beneficial Health Effects of Exercise for Diabetes: Focus on the Liver!
Due to the western lifestyle, correlated with a high calorie intake and low physical
activity, obesity is becoming a major health problem. All over the world obesity reaches
epidemic proportions. Obesity is closely linked to type 2 diabetes, a multi-factorial
disease that increases the presence of multiple health problems. Until now, exercise and
dietary intervention seem to be the single most effective interventions to treat obesity and
type 2 diabetes mellitus. In obesity and type 2 diabetes, not only fat accumulation in
adipose tissue, but also fat accumulation in the peripheral tissues occurs. Fat accumulation
in peripheral tissues has been associated with insulin resistance. Exercise seems to have a
positive effect on the accumulation of fat in the peripheral tissue and on the insulin
sensitivity in type 2 diabetic patients.
In this study we want to investigate if a prolonged exercise training program can lower the
intrahepatic lipid content and can improve the metabolism of the liver in type 2 diabetic
patients and patients with non-alcoholic fatty liver disease, and to examine if this leads
to improvements in metabolic risk markers. To this end, we will include investigation of the
effect of exercise on adipose tissue (inflammatory markers and adipocyte size) and skeletal
muscle (ex vivo lipid metabolism) to incorporate the effect of exercise on liver, muscle and
adipose tissue and to clarify the crosstalk between these tissues in the pathophysiology of
type 2 diabetes.
n/a
Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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