Obesity Clinical Trial
Official title:
Effect of Pharmacological Anti-lipolysis on FFA and VLDL-TG Metabolism Before and During Exercise
This study will investigate free fatty acid and VLDL-TG metabolism before and during exercise with and without pharmacological antilipolysis by the niacin antagonist Acipimox. Main focuses will be VLDL-TG and free fatty acid metabolism as well as expression of membrane proteins in fat- and muscle biopsies.
Insulin resistance in liver and skeletal muscle is of central pathogenic significance in the
development of type 2 diabetes. The molecular connections are unresolved but high levels of
free fatty acids and triglyceride is probably involved. Diabetic subjects and to a lesser
extent obese subjects have increased triglyceride levels, this could be due to an abnormal
turnover of VLDL-TG. It is not yet investigated whether VLDL-TG kinetics changes during
pharmacological antilipolysis. Using the aseptic ex-vivo labeling technique (developed in
our laboratories) we will investigate this issue in sedentary healthy men. After a 3 hour
basal period subjects will exercise on a bike for 60 minutes at 60% of VO2max. In both basal
and exercise period one muscle and one fat biopsy will be obtained, further blood samples
will be drawn to examine FFA and VLDL-TG metabolism etc..
This new knowledge will contribute to the understanding of metabolic disorders like type 2
diabetes and obesity.
;
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science
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