Low Carbohydrate and Conventional Diets Associated to Resistance Training on Muscle Fitness and Health Markers

Obesity Clinical Trial

— LCD-RT  

Official title:

Combined Effects of Resistance Training and Low Carbohydrate or Conventional Diets on Strength, Muscle Mass, Body Composition, Blood Lipids and Endothelium Function

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01096836
• Other study ID #: UGF-01-2010
• Status: Completed
• Phase: N/A
• First received: March 17, 2010
• Last updated: March 30, 2010
• Start date: September 2006
• Est. completion date: August 2008

Study information

• Verified date: November 2007
• Source: Universidade Gama Filho
• Contact: n/a
• Is FDA regulated: No
• Health authority: Brazil: National Committee of Ethics in Research
• Study type: Interventional

Clinical Trial Summary

The purpose of this study was to compare the effects of two different diets (low carbohydrate - LCD and conventional - CONV) on body composition, strength performance, muscle mass and biomarkers of health in overweight adults submitted to resistance training (RT). It has been hypothesized that LCD would produce higher rates of weight loss and that both diets would be useful to maintain muscle mass and strength and biomarkers of health.

Description:

Overweight and obesity prevalence has increased worldwide. Current guidelines recommend health behavior modifications, including better eating habits and regular physical activity (including resistance training - RT) as a strategy to control and prevent the problem. Traditionally, diets poor in energy and fat (conventional diets - CONV) have been recommended to promote losses in body and fat masses; however, there has been recently a growing interest in the academic community to investigate the effects of low carbohydrate diet (LCD) on health outcomes, since this kind of diet appears to be more effective for reducing body mass as compared to CONV. Nevertheless, evidences are scarce regarding the effects of LCD associated to RT on body composition, strength performance, blood lipids, endothelium function and other markers of health, demanding the development of clinical trials aiming to determine the combined health effects of these interventions.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 21
• Est. completion date: August 2008
• Est. primary completion date: January 2008
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• BMI equal or over 25 kg/m2

• resistance trained at least 12 weeks

Exclusion Criteria:

• upper or lower limbs injury

• pregnancy

• diabetes

• use of ergogenics, stimulants or drugs

• history of dislipidemias

• arterial hypertension

Study Design

Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Obesity
• Overweight

Intervention

Other:
• macronutrient and energy manipulation

Locations

Country	Name	City	State
Brazil	Laboratory Crossbridges	Rio de Janeiro	RJ

Sponsors (1)

Lead Sponsor	Collaborator
Universidade Gama Filho

Country where clinical trial is conducted

Brazil, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	body mass	Measured always at the same time of the day on a calibrated weight scale	eight weeks	No
Secondary	Muscle strength	Measured using resistance exercise machines (isotonic) in four exercise movements	eight weeks	No
Secondary	Endothelial function	Measured using a two dimensional color spectral Doppler ultrasound equipped with a 14MHz linear transducer. Subject laid down comfortably in the supine position with the right arm slightly abduced. After locating the brachial artery, the transducer was placed on the anteromedial face of the right arm, perpendicular to the centerline of the arm, 5-10 cm above the antecubital fossa, over the artery.	eight weeks
Secondary	muscle thicknesses	Measured with a ultrasoundo bidimensional in Mode B, with a 7,5MHz transducer on the anatomical sites knee extensor muscles and elbow flexors and extensors.	eight weeks
Secondary	markers of renal function	Measured using conventional and satandardized laboratory methods with subjects fasting for 12 hours	eight weeks
Secondary	body composition	Measured with skinfold calipers and using prediction equations to determine body fat and lean body mass.	eight weeks