Obesity Clinical Trial
— HEPFATOfficial title:
Role of Dietary Fatty Acids in Fatty Liver and Insulin Resistance: a Randomized Controlled Study
Verified date | December 2009 |
Source | Uppsala University |
Contact | n/a |
Is FDA regulated | No |
Health authority | Sweden: Regional Ethical Review Board, Uppsala |
Study type | Interventional |
The purpose of this study is to investigate whether substituting saturated fats with polyunsaturated fats reduces fatty liver and improves insulin action and other metabolic variables in abdominally obese subjects
Status | Completed |
Enrollment | 65 |
Est. completion date | April 2010 |
Est. primary completion date | April 2010 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 30 Years to 65 Years |
Eligibility |
Inclusion Criteria: - abdominal obese subjects with or without type 2 diabetes - sagittal abdominal diameter >25cm Exclusion Criteria: - insulin treatment - history of serious cardiovascular events - morbid obesity - claustrophobia (relative criterion) |
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
Country | Name | City | State |
---|---|---|---|
Sweden | Uppsala University Hospital, Uppsala Science Park | Uppsala |
Lead Sponsor | Collaborator |
---|---|
Uppsala University | Swedish Council for Working Life and Social Research |
Sweden,
Summers LK, Fielding BA, Bradshaw HA, Ilic V, Beysen C, Clark ML, Moore NR, Frayn KN. Substituting dietary saturated fat with polyunsaturated fat changes abdominal fat distribution and improves insulin sensitivity. Diabetologia. 2002 Mar;45(3):369-77. — View Citation
Yki-Järvinen H. Fat in the liver and insulin resistance. Ann Med. 2005;37(5):347-56. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Hepatic steatosis by MRT | 10 weeks | No | |
Secondary | Insulin resistance by oral glucose tolerance test | 10 weeks | No | |
Secondary | Changes in adipose tissue gene expression and lipogenic enzyme activity | 10 weeks | No |
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