Obesity Clinical Trial
Official title:
Vascular Function, Endothelin, and Inflammation in Pre-diabetic Obesity Versus Lean Healthy Controls
Aims:
1. Does inflammation contribute importantly to concurrent defects in vascular and metabolic
dysfunction in human pre-diabetic obesity?
2. Are there benefits of anti-inflammatory treatment strategies in pre-diabetic obesity in
the context of existing treatment with metformin?
3. Are there benefits of anti-inflammatory treatment strategies in pre-diabetic obesity in
the context of existing treatment with lisinopril?
We set out to pursue the following Aims:
1. Does inflammation contribute importantly to concurrent defects in vascular and metabolic
dysfunction in human pre-diabetic obesity? Pilot studies were performed exploring the
acute actions of salsalate on vascular function, the chronic actions of salasate in
obese individuals, and actions of chronic salsalate to prevent vascular dysfunction
induced by fatty acids in lean individuals.
2. Are there benefits of anti-inflammatory treatment strategies in pre-diabetic obesity in
the context of existing treatment with metformin? No studies were performed
3. Are there benefits of anti-inflammatory treatment strategies in pre-diabetic obesity in
the context of existing treatment with lisinopril? No studies were performed
The intent of the current project is to efficiently and at low cost generate preliminary data
along each of these lines of questioning, studying the minimum number of subjects required to
assess the viability of the question using the current measurement approaches.
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