Obesity Clinical Trial - Effects of Human Leptin Replacement

Status Completed

Clinical Trial Summary

This study will test the hypothesis that leptin contributes to the regulation of the dynamics of human endocrine function.

Clinical Trial Description

The study aims to elucidate the role of leptin in the regulation of human endocrine function approached by a carefully designed, prospective clinical study of the rapidly-sampled dynamics of endocrine rhythms during the course of leptin-replacement treatment in the only three adult individuals identified in the world so far who are leptin-naive due to a functional leptin gene mutation. A study of leptin-naive subjects avoids all confounding factors and pitfalls, because the only bioactive leptin to which they will be exposed is the exogenously administered recombinant protein. Thus, this proposal will permit us to ascertain the endocrine effects of human leptin. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00657605
Study type	Interventional
Source	University of Miami
Contact
Status	Completed
Phase	Phase 2
Start date	June 2001
Completion date	May 4, 2010

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