Obesity Clinical Trial
Official title:
Impact of Weight Loss Following Bariatric Surgery on Pulmonary Function in Patients With Morbid Obesity
Increase in body mass index (BMI)is associated with a decrease in expiratory flows.Obesity
is also associated with an increased prevalence of asthma.Consequences of obesity on
respiratory function and on bronchial responsiveness are still to be documented.
This study aims to evaluate, before and after surgery, the impact of a bariatric surgery
(biliopancreatic diversion with duodenal switch)on respiratory function in patients with
morbid obesity .
Our hypothesis is that weight loss following bariatric surgery will induce significant
improvements in pulmonary function and airway responsiveness, and, as a consequence, a
reduction in respiratory symptoms,these changes being correlated with a reduction in
systemic markers of inflammation. Maintenance of weight loss after one year will permit the
persistence of these improvements
Patients will be evaluated before the surgery (time zero), 6 months and one year after their
surgery. A control group of patients on a waiting list for bariatric surgery will be
evaluated at time zero and after 6 months and one year.
At each visit,patients will:
- fill a standardized respiratory questionnaire and a questionnaire on sleep apnea;
questionnaires on asthma control will be completed by patients with asthma.
- have a spirometry, pulmonary volumes measures by body plethysmography and methacholine
inhalation test with evaluation of symptoms perception.
- an induced sputum will be performed.
- A blood sample will be drawn to evaluate inflammation and measure C-reactive protein
concentration in plasma.
- An allergy skin prick test will be done at time zero.
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Observational Model: Cohort, Time Perspective: Prospective
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