Melatonin Metabolism Abnormality in Patients With Schizophrenia or Schizoaffective Disorder Treated With Olanzapine

Obesity Clinical Trial

Official title:

Melatonin Metabolism Abnormality in Patients With Schizophrenia or Schizoaffective Disorder Treated With Olanzapine and Melatonin Dose Finding for the Correction of the Metabolic Abnormality

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT00512070
• Other study ID #: F1D-MC-X302
• Status: Active, not recruiting
• Phase: N/A
• Start date: July 2007
• Est. completion date: December 2025

Study information

• Verified date: February 2023
• Source: Seattle Institute for Biomedical and Clinical Research
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Atypical antipsychotic medications, such as olanzapine, cause metabolic side effects, including weight gain, extra fat around the middle of the body, high blood sugar, and high cholesterol. One of the mechanisms by which these medications may cause these effects is by reducing plasma melatonin. This study is a pilot project to evaluate 1) the effect of olanzapine on melatonin secretion levels and 2) the effect of melatonin on olanzapine-induced changes in melatonin secretion in patients with schizophrenia, schizoaffective, or bipolar disorder.

Description:

To investigate the relationship between olanzapine, melatonin, and metabolic functioning, this pilot study is evaluating 20 patients with schizophrenia, schizoaffective disorder, or bipolar disorder over 15 weeks under three experimental conditions: 1) baseline (two weeks treatment with already established antipsychotic medication other than olanzapine or clozapine), 2) six weeks treatment with olanzapine only, and 3) six weeks treatment with olanzapine and melatonin. Half of the patients will receive 0.3 mg of oral melatonin and half will receive 3.0 mg of melatonin. Nocturnal melatonin production, as estimated by assay of urinary 6-sulfatoxymelatonin(aMT6s) adjusted for creatinine, will be measured weekly. In addition, weekly measurements of weight and other metabolic indices, including waist and hip measurements, fasting glucose, serum insulin, cholesterol, triglycerides, and leptin will be taken. It is anticipated that there will be an olanzapine-induced decrease in melatonin production. Furthermore, it is expected that the decrease in melatonin production associated with olanzapine treatment will be reversed by administration of melatonin with olanzapine.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 20
• Est. completion date: December 2025
• Est. primary completion date: December 2025
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

1. Age 18-65;

2. DSM-IV-TR diagnosis of schizophrenia, schizoaffective disorder, or bipolar disorder;

3. Patients who, in the clinical judgment of the investigator, may benefit from a switch to olanzapine;

4. Females must be of non-child bearing potential (i.e., surgically sterilized, or at least one year post-menopausal) or on an appropriate dose of oral/depot contraceptives or using barrier protection and not breast-feeding. Females must have a urine pregnancy test at screening;

5. Willingness and ability to take medications nightly at 10:00 p.m.; and

6. The subject or his/her legal representative must provide informed, written consent.

Exclusion Criteria:

1. Females who are pregnant or lactating;

2. Concurrent participation or participation within the prior 30 days in any study involving investigational medications;

3. Current (within the prior 30 days) diagnosis of substance abuse or dependence;

4. Use of olanzapine within the prior three months;

5. History of allergy or intolerable side-effects to olanzapine in the past;

6. History of significant head trauma, defined as head trauma resulting in loss of consciousness for more than five minutes and/or neurological or cognitive sequelae;

7. Evidence of any clinically relevant disease (e.g., renal or hepatic impairment, significant coronary artery disease, cerebrovascular disease, or cancer) or any clinical finding that in the opinion of the investigator could potentially be negatively affected by study participation or that could potentially affect study participation is criterion for exclusion from the study;

8. Use of fluvoxamine, nifedipine, or warfarin for 30 days prior to Baseline Visit.

Related Conditions & MeSH terms

• Bipolar Disorder
• Congenital Abnormalities
• Disease
• Metabolic Syndrome
• Obesity
• Psychotic Disorders
• Schizoaffective Disorder
• Schizophrenia

Intervention

Drug:
• olanzapine and melatonin
In treatment phase I, all subjects will receive olanzapine, 10-25 mg/day. In treatment phase II, all subjects will receive olanzapine (10-25 mg/day) plus melatonin. Subjects will be randomized at a ratio of 1:1 to receive melatonin, 0.3 mg/day or 3.0 mg/day. Group IIA will receive 0.3mg day melatonin. Group IIB will receive 3.0 mg/day melatonin.

Locations

Country	Name	City	State
United States	VA Puget Sound Health Care System	Tacoma	Washington

Sponsors (2)

Lead Sponsor	Collaborator
Seattle Institute for Biomedical and Clinical Research	Eli Lilly and Company

Country where clinical trial is conducted

United States, 

References & Publications (1)

Raskind MA, Burke BL, Crites NJ, Tapp AM, Rasmussen DD. Olanzapine-induced weight gain and increased visceral adiposity is blocked by melatonin replacement therapy in rats. Neuropsychopharmacology. 2007 Feb;32(2):284-8. doi: 10.1038/sj.npp.1301093. Epub 2006 May 10. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Nocturnal melatonin production as estimated by assay of urinary 6-sulfatoxymelatonin (aMT6s) adjusted for creatinine	Nocturnal melatonin production as estimated by assay of urinary	6 and 12 weeks
Secondary	Height	height (measured in feet and inches)	6 weeks
Secondary	Height	height (measured in feet and inches)	12 weeks
Secondary	Weight	weight (measured in pounds)	6 weeks
Secondary	Weight	weight (measured in pounds)	12 weeks
Secondary	Waist measurement	waist measurement (measured in inches)	6 weeks
Secondary	Waist measurement	waist measurement (measured in inches)	12 weeks
Secondary	Hip measurement	hip measurement (measured in inches)	6 weeks
Secondary	Hip measurement	hip measurement (measured in inches)	12 weeks
Secondary	Metabolic test	metabolic blood panel	6 weeks
Secondary	Metabolic test	metabolic blood panel	12 weeks