Obesity Clinical Trial
Official title:
The Role of the Omentum in the Treatment of Morbid Obesity
The purpose of this research is to determine some of the reasons that blood sugar and insulin levels improve after bariatric surgery but before weight loss begins, as well as why people respond differently to weight loss surgery. It will also examine whether removing the fat around the stomach and large intestine (the omentum) will improve weight loss. Finally, it will see why there are differences between Whites and African Americans who have weight loss surgery.
The purpose of this research is to tease out the mechanisms related to changes in insulin
sensitivity, metabolism, hormones, and body composition following bariatric surgery. Because
preliminary data indicate differing responses to this surgery, both Caucasian and African
American adults, scheduled for RYGB, are being recruited to participate. It is believed that
the omentum contributes to hepatic insulin resistance, both because of the increased
delivery of NEFAs via the portal vein, and the increased production of cytokines. Because of
this, it is postulated that removing the omentum as part of bariatric surgery will speed up
the reversal of insulin resistance and diminish racial differences in response to the
surgery.
Data are derived from tissue and blood samples obtained operatively (from individuals having
bariatric surgery and other abdominal operations), as well as during
hyperinsulinemic-euglycemic clamps, from indirect calorimetry, DEXA, Health-related Quality
of Life surveys, and 24-hour urine samples. There were 66 participants randomized to
omentectomy/no omentectomy. A post hoc data power analysis determined that this number of
subjects is sufficient for data analysis.
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