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Biologic Effects of Dehydroepiandrosterone (DHEA) in Humans

Obesity Clinical Trial

Official title:
Biologic Effects of DHEA in Humans

Clinical Trial Summary

The purpose of this study is to determine whether DHEA replacement therapy decreases abdominal fat and improves insulin sensitivity.

Clinical Trial Description

Studies on rats and mice have shown that the adrenal hormone dehydroepiandrosterone (DHEA) reduces abdominal visceral fat and protects against insulin resistance. This study was done to learn if DHEA replacement therapy decreases abdominal obesity and improves insulin action in humans.

Participants were randomly assigned to receive 50 mg per day of DHEA or a placebo at bedtime for 6 months. Participants underwent magnetic resonance imaging (MRI) and oral glucose tolerance tests at the beginning and conclusion of the study. Other tests included measurements of hormones and lipids. ;

Study Design

Allocation: Randomized, Masking: Double-Blind, Primary Purpose: Prevention

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00099697
Study type Interventional
Source National Institute on Aging (NIA)
Contact
Status Completed
Phase N/A
Start date June 2001
Completion date February 2004
View Details
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