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Obese clinical trials

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NCT ID: NCT06040372 Completed - Healthy Clinical Trials

A First in Human Study to Assess the Safety, Tolerability of LB54640 in in Healthy Overweight and Obese Subjects

Start date: March 16, 2020
Phase: Phase 1
Study type: Interventional

The aim of this 4-weeks randomized double-blind placebo-controlled single and multiple ascending dose study is to assess the Safety and Tolerability of LB54640 in Healthy overweight and obese subjects

NCT ID: NCT05979129 Recruiting - Obese Clinical Trials

Gastric Insufflation During Facemask Ventilation at Different Levels of End-expiratory Pressure in Obese Patients

Start date: August 6, 2023
Phase: N/A
Study type: Interventional

Gastric insufflation occurs when the inspiratory pressure exceeds the lower esophageal sphincter pressure. Thus, it is desirable to avoid excessive positive pressure during mask ventilation after induction of anesthesia and keeping the inspiratory pressure <15-20 cmH2O.In patients with obesity the lower compliance of the respiratory system usually requires higher inspiratory pressures to maintain adequate ventilation making these patients more prone to gastric insufflation. This high risk of gastric insufflation can be aggravated by the use of positive end-expiratory pressure (PEEP) which is recommended to avoid lung atelectasis. The application of PEEP during mask ventilation increases the risk of gastric insufflation as it reduces the pressure threshold at which gastric insufflation occur The optimum ventilatory strategy during mask ventilation should achieve the balance between adequate lung ventilation and avoiding gastric insufflation. In obese patients, it is not clear whether the use of PEEP during mask ventilation would increase the risk of gastric insufflation or not. We hypothesize that using zero end-expiratory pressure (ZEEP) or low PEEP during mask ventilation would reduce the risk of gastric insufflation in comparison to high PEEP.

NCT ID: NCT05878444 Not yet recruiting - Obese Clinical Trials

Evaluation of the Colonization Capacity of a Probiotic Bacterium.

BIOPRED
Start date: June 1, 2023
Phase: Phase 1
Study type: Interventional

The goal of this interventional study is to test the colonization of a new generation probiotic in normal weight and overweight/obese people. The main question aims to answer is if our bacteria is able to colonize the human intestine. Participants will recieve a probiotic pill every day during 15 consecutive days and fill in questionaries.

NCT ID: NCT05865145 Recruiting - Elderly Clinical Trials

Effects of Aerobic Exercise on Basic Metabolic Panel Perceived Exertion and Exercise Adherence in Elderly

Start date: May 2023
Phase: N/A
Study type: Interventional

Participants were randomly assigned to two groups prior to their second visit: the High intensity interval training group A (HIIT) and Low intensity interval training group B (LIIT). The randomization processes were conducted in Excel utilizing a random-number generator. Prior to the second visit, each participants' target exercise heart rate ranges were determined. Group A will receive a program of high intensity interval training program Group B will receive a program of Low intensity interval training program

NCT ID: NCT05857150 Recruiting - Obese Clinical Trials

Exercise Response in Humans With Obesity

Start date: September 22, 2023
Phase:
Study type: Observational

This study is being done to understand how chronic inflammation affects muscle function and responses to exercise.

NCT ID: NCT05846100 Recruiting - Cesarean Section Clinical Trials

Conventional Palpation Versus Ultrasound Assisted Spinal Anesthesia in Obstetrics

Start date: November 1, 2022
Phase: N/A
Study type: Interventional

Spinal anesthesia in obese parturients is commonly difficult yet there are no guidelines to direct best practice. The failure leads to suboptimal patient outcomes. Ultrasonography is now considered standard care for central venous access and regional anesthesia and it can be used to visualize the anatomy of the spine for this procedure. Goal of the study Evaluate the benefits of preprocedural ultrasound scanning to facilitate neuraxial anesthesia and improve the first-attempt success rate in obese parturients.

NCT ID: NCT05844644 Recruiting - Type 2 Diabetes Clinical Trials

The Effects of the GOLO for Life® Plan With Release Supplement on Glycemic Control and Weight in Overweight and Obese Adults With Prediabetes or Type 2 Diabetes

Start date: April 20, 2023
Phase: Phase 2
Study type: Interventional

The objective of this study is to investigate the efficacy and safety of the GOLO for Life® Plan (G4LP) and Release supplementation on glycemic control and weight in overweight and obese adults with Prediabetes or Type 2 Diabetes. The change in glycemic control from baseline at Days 90 and 180 following the G4LP and supplementation with Release will be assessed. Additionally, the safety and tolerability of the G4LP and Release supplementation will be measured by the occurrence of and/or changes in pre-emergent and post-emergent adverse events (AEs).

NCT ID: NCT05844631 Completed - Overweight Clinical Trials

The Effects of the GOLO for Life® Plan and Release Supplement on Weight Management in Overweight and Obese Adults

Start date: April 20, 2023
Phase: Phase 2
Study type: Interventional

The objective of this study is to investigate the efficacy and safety of the GOLO for Life® Plan (G4LP) and Release supplementation on weight loss, body composition, and cardiometabolic parameters in overweight and obese adults. The change from baseline at Days 90 and 180 following the G4LP and supplementation with Release in weight (kg and % of total weight) and fat mass (percent and kg) will be assessed by Dual X-Ray Absorptiometry (DEXA). The weekly change in weight (kilograms and percent change) will also be assessed from baseline to day 180 following the G4LP and Release supplementation. Additionally, the safety and tolerability of the G4LP and Release supplementation will be measured by the occurrence of and/or changes in pre-emergent and post-emergent adverse events (AEs).

NCT ID: NCT05841238 Completed - Healthy Clinical Trials

A Multiple Dose Study of LY3502970 in Healthy Overweight and Obese Participants

Start date: April 26, 2023
Phase: Phase 1
Study type: Interventional

The main purpose of this study is to evaluate how much LY3502970 gets into the bloodstream and how long it takes the body to eliminate when administered orally as tablet and capsule formulations along with effect of food on LY3502970 in healthy overweight and obese participants. The study will also evaluate the safety and tolerability of LY3502970 in these participants. The study is conducted in two parts (part A and B) and will last up to 135 days including the screening period.

NCT ID: NCT05835752 Recruiting - Healthy Clinical Trials

The Safety, Tolerability and Pharmacokinetic Study of RAY1225

Start date: May 18, 2023
Phase: Phase 1
Study type: Interventional

This trial is conducted in China. The aim of the trial is to investigate safety, tolerability, pharmacokinetics and pharmacodynamics of RAY1225