Tissue Doppler Ultrasound During Spontaneous Breathing & Non-invasive

Status Recruiting

Clinical Trial Summary

The aim of the present investigation will be to evaluate diaphragmatic excursion velocity during non-invasive ventilation and spontaneous breathing at both inspiration and expiration.

this analysis will be performed through diaphragmatic tissue Doppler assessment.

Clinical Trial Description

Early weaning from invasive ventilation, in patients admitted to intensive care, is associated with a marked reduction in ventilator-associated pneumonia, length of stay in intensive care unit and hospital, total duration of mechanical ventilation and decrease in overall mortality. Moreover, in case of need of protected extubation, non-invasive ventilation has allowed to prevent re-intubation and decrease hospital mortality compared to the simple administration of oxygen through a facial mask, in particular when applied immediately after extubation.

The diaphragmatic tissue doppler imaging (TDI) is an ultrasonographic technique derived from ultrasound evaluation of the heart's motility. It can be easily used on the diaphragm to calculate the speed of muscles displacement that could be associated with patient's respiratory drive.

The aim of the study is the evaluation of the diaphragmatic excursion velocity variations using diaphragmatic tissue doppler, measured in venturi mask and non-invasive ventilation in the post-extubation period, in order to compare the diaphragm stress variations during the two different modes.

Method Patients after extubation will be randomly submitted to a spontaneous breathing test in venturi mask and in facemask or helmet NIV.

Each trial will last 20 minutes. During the last minute of each trial a tissue doppler diaphragm examination will be performed to assess the speed speed of muscle displacement, acceleration and deceleration.

Inclusion criteria: invasive mechanical ventilation > 24h with consequent extubation.

Exclusion criteria: refusal to grant consent, pregnancy, age < 18 years, haemodynamic instability, difficult management of secretions, required inotropic and / or vasoactive drugs at high doses.

During the study, vital parameters will be given. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03978221
Study type	Interventional
Source	Azienda Ospedaliero Universitaria Maggiore della Carita
Contact	Gianmaria Cammarota, MD,PHD
Phone	00393392669420
Email	gmcamma@gmail.com
Status	Recruiting
Phase	N/A
Start date	April 1, 2019
Completion date	April 1, 2020

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05144633` - Blue Protocol and Eko Artificial Intelligence Are Best (BEA-BEST)
Completed	`NCT04534569` - Expert Panel Statement for the Respiratory Management of COVID-19 Related Acute Respiratory Failure (C-ARF)
Recruiting	`NCT03021902` - Nutrition and Exercise in Critical Illness	Phase 2
Completed	`NCT02902146` - Bougie Use in Emergency Airway Management	N/A
Completed	`NCT02901158` - Esophageal Manometry in Mechanically Ventilated Patients
Completed	`NCT02236559` - High Flow Therapy for the Treatment of Respiratory Failure in the ED	N/A
Recruiting	`NCT02056093` - Comparison of Proportional Assist Ventilation And Neurally Adjusted Ventilator Assist	N/A
Terminated	`NCT01083277` - Variable Ventilation During Acute Respiratory Failure	N/A
Not yet recruiting	`NCT01668368` - Goal Directed Mechanical Ventilation Aimed at Optimal Lung Compliance	N/A
Completed	`NCT01462279` - Effect of Thiamine on Oxygen Utilization (VO2) in Critical Illness	N/A
Completed	`NCT01114022` - Prevention Inhalation of Bacterial by Using Endotracheal Tube Balloon Polyvinyl Chloride or Polyurethane	N/A
Active, not recruiting	`NCT01058421` - Treatment of Critical Illness Polyneuromyopathy	Phase 2
Completed	`NCT00252616` - Timing of Target Enteral Feeding in the Mechanically Ventilated Patient	Phase 2/Phase 3
Recruiting	`NCT04098094` - Outcomes of RV Dysfunction in Acute Exacerbation of Chronic Respiratory Diseases
Recruiting	`NCT06051292` - Decremental Esophageal Catheter Filling Volume Titration For Transpulmonary Pressure Measurement	N/A
Completed	`NCT04601090` - Survival Rates and Longterm Outcomes After COVID-19
Recruiting	`NCT05423301` - Global Physiotherapy in ICU Patients With High Risk Extubation Failure	N/A
Completed	`NCT02447692` - Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: The PROMIZING Study	N/A
Completed	`NCT04016480` - HFNC During Bronchoscopy for Bronchoalveolar Lavage	N/A
Completed	`NCT04507425` - High Flow Nasal Cannula With Noninvasive Ventilation	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Tissue Doppler Ultrasound During Spontaneous Breathing and Non-invasive Ventilation in the Post-extubation Period. — TDIpostext

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms