High Flow Therapy for the Treatment of Respiratory Failure in the ED

Status Completed

Clinical Trial Summary

The overall objective of this study is to determine if Vapotherm high flow nasal cannula therapy (HFT), when used to treat respiratory failure in the ED, is at least equivalent to the current standard of care for non-invasive ventilatory support, non-invasive positive pressure mask ventilation (NIPPV). Moreover, this study will investigate the potential that HFT has possible advantages over NIPPV, such as decreased time to patient stability from respiratory failure, and the ease of use as a first line intervention for respiratory failure in the ED environment.

The hypothesis is that HFT via the Vapotherm Precision Flow will demonstrate clinical non-inferiority when compared to NIPPV with regard to treatment failure by way of an impact on ventilation indices and a lower intolerance rate, and have a positive association with hospital disposition and length of stay.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Acute Respiratory Failure
Respiratory Distress Syndrome, Adult
Respiratory Insufficiency

Clinical Trial Details

NCT number	NCT02236559
Study type	Interventional
Source	Vapotherm, Inc.
Contact
Status	Completed
Phase	N/A
Start date	September 2014
Completion date	February 2017

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05144633` - Blue Protocol and Eko Artificial Intelligence Are Best (BEA-BEST)
Completed	`NCT04534569` - Expert Panel Statement for the Respiratory Management of COVID-19 Related Acute Respiratory Failure (C-ARF)
Recruiting	`NCT03021902` - Nutrition and Exercise in Critical Illness	Phase 2
Completed	`NCT02902146` - Bougie Use in Emergency Airway Management	N/A
Completed	`NCT02901158` - Esophageal Manometry in Mechanically Ventilated Patients
Recruiting	`NCT02056093` - Comparison of Proportional Assist Ventilation And Neurally Adjusted Ventilator Assist	N/A
Not yet recruiting	`NCT01668368` - Goal Directed Mechanical Ventilation Aimed at Optimal Lung Compliance	N/A
Terminated	`NCT01083277` - Variable Ventilation During Acute Respiratory Failure	N/A
Completed	`NCT01462279` - Effect of Thiamine on Oxygen Utilization (VO2) in Critical Illness	N/A
Completed	`NCT01114022` - Prevention Inhalation of Bacterial by Using Endotracheal Tube Balloon Polyvinyl Chloride or Polyurethane	N/A
Active, not recruiting	`NCT01058421` - Treatment of Critical Illness Polyneuromyopathy	Phase 2
Completed	`NCT00252616` - Timing of Target Enteral Feeding in the Mechanically Ventilated Patient	Phase 2/Phase 3
Recruiting	`NCT04098094` - Outcomes of RV Dysfunction in Acute Exacerbation of Chronic Respiratory Diseases
Recruiting	`NCT06051292` - Decremental Esophageal Catheter Filling Volume Titration For Transpulmonary Pressure Measurement	N/A
Completed	`NCT04601090` - Survival Rates and Longterm Outcomes After COVID-19
Completed	`NCT02447692` - Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: The PROMIZING Study	N/A
Completed	`NCT04016480` - HFNC During Bronchoscopy for Bronchoalveolar Lavage	N/A
Completed	`NCT04507425` - High Flow Nasal Cannula With Noninvasive Ventilation	N/A
Active, not recruiting	`NCT04079829` - Postoperative Respiratory Abnormalities
Completed	`NCT04067622` - Novel Arm Restraint For Critically Ill Patients To Reduce Immobility, Sedation, Agitation and Cognitive Impairment	N/A