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Neurogenic Bladder clinical trials

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NCT ID: NCT06247033 Active, not recruiting - Stroke Clinical Trials

Efficacies of Different Managements in Patients With Overactive Bladder With Stroke

Start date: November 1, 2022
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to comparing the efficacies of different managements in patients with overactive bladder symptoms with stroke The main question it aims to answer are: - Are pelvic floor training exercises and bladder training enough to ease the symptoms of overactive bladder in patients with stroke? - Is tibial nerve stimulation really effective and does it decrease the need of medications in patients with overactive bladder with stroke? Participants are questioned if they have the symptoms of overactive bladder. After urodynamic evaluation, they are separated in 2 groups. Pelvic floor training exercises and bladder training are given in both groups; while one of the groups is followed with tibial nerve stimulation and the other one is followed with sham tibial nerve stimulation for 6 weeks. Our main aim was to compare effectiveness of tibial nerve stimulation in patiens with overactive bladder with stroke.

NCT ID: NCT06163469 Recruiting - Urinary Retention Clinical Trials

Effect of Chlorhexidine Gluconate Bladder Instillations in Patients With Chronic Suprapubic Catheters on Unplanned Healthcare Encounters and Quality of Life

Start date: February 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to evaluate the feasibility and tolerability of 0.05% Chlorhexidine Gluconate (CGH) bladder instillations in an outpatient setting at the time of suprapubic catheter (SPC) exchange in patients with history of recurrent urinary tract infections (UTI). The main questions are: 1. is instillation of 150mL of CGH for five-minute duration at the time of SPC exchange feasible in an outpatient setting and tolerable for patients. 2. does this protocol decrease the rate of unplanned health care visits and improve patient quality of life. Patients will undergo the treatment protocol during their routine suprapubic catheter exchanges.

NCT ID: NCT06072703 Recruiting - Multiple Sclerosis Clinical Trials

Neuromodulating Cortical Regions Involved in Neurogenic Bladder in MS

MSBLADDER
Start date: March 30, 2023
Phase: N/A
Study type: Interventional

Neurogenic overactive bladder (NOAB), characterized by urinary frequency, urgency or urgency incontinence symptoms occurring during the storage phase of the bladder, is the most common urinary complaint in multiple sclerosis (MS). Current management options for NOAB in MS have limited efficacy and considerable adverse effects, which underscores the significance of this study and highlights the need for better, less invasive therapies. This novel study investigates brain therapeutic targets that could shift the focus of NOAB management in MS from a bladder-centric focus to brain restoration; specifically modulating the brain regions identified in the prior functional magnetic resonance imagining studies. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive brain stimulation that can modulate neurons (excite or inhibit) to improve the connectivity of the regions of interest (ROI). The preliminary data demonstrate, for the first time, significant improvement in bladder symptoms in ten women with MS who have voiding dysfunction following multifocal transcranial magnetic stimulation without any treatment-related adverse effects. This randomized double-blind, sham-controlled single center clinical trial with an optional open-label extension (OLE) phase is designed to evaluate the effects of targeted rTMS in women with MS and NOAB by investigating restorative reorganization of brain function The main purpose of this study is to determine the effects of individualized repetitive Transcranial Magnetic Stimulation (rTMS) for improving overactive bladder symptoms such as urinary frequency and urgency with or without incontinence in individuals with multiple sclerosis (MS). Patients will undergo initial screening that includes a demographics information, physical exam, past medical and surgical history, medication list, urine pregnancy test (female subjects with childbearing potential), and completion of questionnaires to confirm the eligibility of patients. All eligible patients will be required to complete a functional MRI scan followed by locating the regions of interest through neural navigation system and finally receiving 10 treatment sessions. Since this is a randomized trial, some patients will receive active treatment/ therapy sessions while others will only receive sham or placebo treatments. The total duration to complete all treatment sessions and follow up visits is approximately 4-5 months.

NCT ID: NCT06059066 Recruiting - Overactive Bladder Clinical Trials

Optimization of OnabotulinumtoxinA (BTX-A) Injection for the Treatment of Neurogenic Lower Urinary Tract Dysfunction

BOND
Start date: October 4, 2023
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate and standardize the way providers perform OnabotulinumtoxinA (BTX-A) injections into the bladder for the diagnosis of neurogenic lower urinary tract dysfunction (NLUTD)/overactive bladder (OAB). NLUTD/OAB is a syndrome that affects many people, and includes urinary frequency, urinary urgency, urgency incontinence, and nocturia. This syndrome can be challenging to treat and often requires procedural management - including BTX-A injections into the bladder.

NCT ID: NCT05861024 Completed - Child, Only Clinical Trials

Urinary Calculi After Bladder Augmentation in Children

LITAVPED
Start date: November 20, 2022
Phase:
Study type: Observational

The goal of this observational study is to analyse the occurence of urinary calculi after bladder augmentation in children: - location of the calculi (kidney or bladder) - type of bladder augmentation with higher rate of urinary calculi and why - Find risk factors of urinary calculi in bladder augmentation (age, sex, other bladder procedures..)

NCT ID: NCT05861011 Completed - Neurogenic Bladder Clinical Trials

Bladder Neck Surgery in Children With Neurogenic Bladder

CERPED
Start date: January 1, 2020
Phase:
Study type: Observational

Surgical outcomes of bladder neck surgery in children with neurogenic bladder. Consequences on bladder voiding.

NCT ID: NCT05858840 Completed - Child, Only Clinical Trials

Urinary Artificial Sphincter in Children

SUA
Start date: November 20, 2022
Phase:
Study type: Observational

Retrospective monocentric study of the outcomes of patients with neurogenic bladder, who had a urinary artificial sphincter before the age of 18 years old. Hypothesis: what was the impact of the urinary artificial sphincter on the global management of the patient.

NCT ID: NCT05840874 Enrolling by invitation - Child, Only Clinical Trials

Complications of Enterocystoplasty in Children

AVPED
Start date: March 1, 2023
Phase:
Study type: Observational

The goal of this observational study is to describe the complications in participants who underwent enterocystoplasty in childhood. The main question[s] it aims to answer are: - what kind of complications are there - the kind of complications depending on the type of enterocystoplasty Participants data will be collected in the medical field. There is no comparison group.

NCT ID: NCT05809154 Withdrawn - Clinical trials for Lower Urinary Tract Symptoms

Study of Patients With Lower Urinary Tract Dysfunction Undergoing Urodynamic Examination for the Assessment of Quality, Cost and Treatment Success

UroLUTS
Start date: January 2019
Phase:
Study type: Observational [Patient Registry]

Lower urinary tract dysfunction (LUTD) is a very common complication of urological, gynecological, neurological, metabolic, inflammatory or tumor disease. LUTD is not an inevitable condition, the investigators can help in many ways. Modern clinical examinations like urodynamics allow for patient tailored treatment strategies. Urodynamics however, even if minimal invasive, may lead to urinary tract infections and are very expensive4. Aim of this study is to evaluate in the long-term perspective what patients profit of urodynamic examinations and in what patients the investigators could resign to perform urodynamics in the future and or in what patients the interval of urodynamics could be extended. Main objective is to follow in a long-term prospective cohort study, patients suffering of lower urinary tract dysfunction (LUTD). In this observational study the investigators will include all patient undergoing clinical routine urodynamic examination to better address what is the normal course of LUTD with and without Treatment. The aim is to have a prospective urodynamics database allowing to answer questions related to urodynamics.

NCT ID: NCT05726786 Recruiting - Bladder Cancer Clinical Trials

The Role of Preoperative Immunonutrition on Morbidity and Immune Response After Cystectomy (INCyst Trial)

INCyst
Start date: April 10, 2023
Phase: Phase 3
Study type: Interventional

The goal of this clinical trial research study is to evaluate the impact of preoperative oral immunonutrition (IN) on post-operative complications in patients undergoing a cystectomy. As a secondary focus, this study will aim to develop a signature that would identify patients that would benefit the most from IN. This is a multicentric (Swiss: N=3), prospective, controlled, pragmatic, parallel-group comparative study with block randomization stratified by centers.