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Nervous System Diseases clinical trials

View clinical trials related to Nervous System Diseases.

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NCT ID: NCT03504254 Completed - Neurologic Disorder Clinical Trials

A fMRI Study of Compressive Spinal Cord

CSM Plasticity
Start date: January 11, 2012
Phase:
Study type: Observational

Cervical myelopathy (CM), a chronically compressive spinal cord lesion, is the most common cause of non-traumatic paraparesis/quadriparesis among the elderly. Hong Kong is facing a heavy social economic burden from CM with the rapidly aging population. Surgical decompression is considered as the mainstay of the treatment for CM patients to relieve their symptoms and signs. Yet the surgical outcome is not always satisfactory. There is a pressing need for understanding the exact mechanism of surgical decompression on the recovery of myelopathic cord in order to improve the prognosis of CM patients in near future.This project will evaluate neuronal activities and axon regeneration by longitudinally monitoring at time zero, 3 and 6 month after the surgery in CM patients using UTE, BOLD-fMRI and DTI, and to investigate the relationship of preoperative neuronal activities of myelopathic cord with axon regeneration.

NCT ID: NCT03490539 Completed - Autoimmune Diseases Clinical Trials

Disease-Modifying Treatments for Myasthenia Gravis

PROMISE-MG
Start date: May 7, 2018
Phase:
Study type: Observational [Patient Registry]

This study is designed to address the evidence gaps in a real-world setting and help patients with MG choose treatments that are best suited to them. It is a prospective, multicenter observational cohort study of comparative effectiveness of MG treatments, with a patient-centered primary outcome measure, to guide clinicians, patients and payers regarding the choice of treatment options for this chronic and serious disease. Primary: To compare the effectiveness of azathioprine (AZT) and mycophenolate mofetil (MMF). Secondary: To compare the outcomes in patients receiving an adequate dose and duration of AZT or MMF over the 2-3 year study period, vs. patients not receiving adequate doses and duration of these agents

NCT ID: NCT03481777 Completed - Ischemic Stroke Clinical Trials

Remote Ischemic Conditioning in Patients With Acute Stroke (RESIST)

RESIST
Start date: March 15, 2018
Phase: N/A
Study type: Interventional

Our primary aim is to investigate whether remote ischemic conditioning (RIC) as an adjunctive treatment can improve long-term recovery in acute stroke patients as an adjunct to standard treatment.

NCT ID: NCT03476408 Completed - Fall Clinical Trials

Plantar Sensation, Balance, Risk of Falling and Gait in Patients With Schizophrenia

Start date: April 20, 2017
Phase: N/A
Study type: Interventional

Cerebellar vermis anomalies are present in schizophrenic individuals. This condition leads to postural balance problems. Foot and ankle complex have a special role for maintaining balance. However, there is no study about this topic in schizophrenic individuals.

NCT ID: NCT03471923 Completed - Clinical trials for Nervous System Diseases

Non-Motor Features of Cervical Dystonia (CD)

Start date: March 26, 2018
Phase:
Study type: Observational

This study will examine the prevalence of four previously identified non-motor markers in a population of cervical dystonia patients, unaffected family members, and healthy volunteers in an attempt to identify a distinct combination of non-motor symptoms that may be indicative of disease development.

NCT ID: NCT03460886 Completed - Stroke Clinical Trials

Most Effective Stimulation Site in Transcranial Direct Current Stimulation for Gait Recovery After Stoke

Start date: February 1, 2018
Phase: N/A
Study type: Interventional

The aim of this study is to investigate the most effective stimulation site in transcranial direct current stimulation for gait recovery after stroke. All subjects will go through four conditions of transcranial direct current stimulation with for 30 minutes. Four conditions are 1) bihemispheric stimulation - anodal stimulation on both ipsilesional and contralesional leg area of primary motor cortex and supplementary motor area. 2) ipsilesional stimulation - anodal stimulation on ipsilesional leg area of primary motor cortex and supplementary motor area. 3) contralesional stimulation - anodal stimulation on contralesional leg area of primary motor cortex and supplementary motor area. 4) sham stimulation. Subjects will walk on treadmill for 10 minutes during transcranial direct current stimulation. Motor evoked potential and functional evaluations will be done before and after stimulation to measure the changes.

NCT ID: NCT03460587 Completed - Stroke Clinical Trials

Long-term Telerehabilitation for Patients With Stroke

Start date: August 29, 2018
Phase: N/A
Study type: Interventional

The aim of the current protocol is to study 40 patients, each for 12 weeks, to address hypotheses related to the ability of a telerehabilitation system to (a) improve motor status and disability, (b) collect various forms of patient data from the home, (c) improve risk factor knowledge and control, and (d) assess patient compliance with home-based telerehabilitation. Patients who have returned to their home after stroke will be provided with a telehealth system and be asked to use it 6 days/week for 12 weeks, during which time subjects will use this system for daily rehabilitation therapy, assessments, and education--all on one platform.

NCT ID: NCT03448159 Completed - Stroke Clinical Trials

Fluoxetine Opens Window to Improve Motor Recovery After Stroke

FLOW
Start date: January 1, 2019
Phase: Phase 2
Study type: Interventional

The FLOW trial is a randomized placebo-controlled trial analyzing the effect of coupling an anti-depressant, fluoxetine (Prozac), and exercise to improve motor recovery following a stroke.

NCT ID: NCT03442049 Completed - Multiple Sclerosis Clinical Trials

Effects of Core Stability Training on Gait in Multiple Sclerosis Patients

Start date: January 1, 2015
Phase: N/A
Study type: Interventional

Gait and mobility are among the functions frequently affected in Multiple Sclerosis (MS) and have a negative impact on quality of life. Strength losses in lower limb muscles, ataxia, sensory problems and fatigue are the most important reasons of walking problems in patients with MS. In addition to loss of strength and tonus problems, especially biomechanical disorders can be seen on foot and this problem affects gatin and balance negatively. The stabilizing muscles, defined as the "core" region and enveloping the body like a corset, are active in the context of postural preparation prior to lower extremity movements and stabilize for the limb movements to be performed. The aim of this study was to investigate the effects of spinal stabilization exercises on walking performance, fatigue, plantar pressure distribution, balance, muscle strength and quality of life in patients with Multiple Sclerosis.

NCT ID: NCT03440034 Completed - Clinical trials for Nervous System Diseases

Study of Pioglitazone in Sporadic Inclusion Body Myositis

Start date: May 22, 2018
Phase: Phase 1
Study type: Interventional

A study looking at the effect of pioglitazone in skeletal muscle of patients with sporadic inclusion body myositis (sIBM).