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Nephrolithiasis clinical trials

View clinical trials related to Nephrolithiasis.

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NCT ID: NCT04374188 Recruiting - Nephrolithiasis Clinical Trials

Efficacy of Ciprofloxacin Therapy in Avoidance of Sepsis in Patient Undergoing Percutanous Nephrolithotomy

Start date: September 1, 2019
Phase: N/A
Study type: Interventional

Efficacy of ciprofloxacin therapy in avoidance of sepsis in patient undergoing percutanous nephrolithotomy. A randomized controlled trial.

NCT ID: NCT04370093 Recruiting - Clinical trials for Nephrolithiasis, Uric Acid

Pathogenesis of Uric Acid Nephrolithiasis: Role of Pioglitazone/Weight Loss

Start date: October 17, 2019
Phase: Phase 4
Study type: Interventional

The investigators will randomize overweight and obese iuan patients to Pio (45 mg/day, highest approved dose or placebo), WL (10% of body weight, following the established program used in the Diabetes Prevention Program), or Pio+WL. Participants will be evaluated at baseline and after 24 weeks of intervention while on a fixed metabolic diet to exclude the confounding effects of diet and perspiration. The primary endpoint will be change in upH, and multiple additional endpoints (serum, urine, imaging) will be assessed.

NCT ID: NCT04367155 Recruiting - Nephrolithiasis Clinical Trials

Efficacy of Tranexamic Acid on Blood Loss During Percutaneous Nephrolithotomy.

Start date: September 1, 2019
Phase: N/A
Study type: Interventional

Efficacy of tranexamic acid on blood loss during percutaneous nephrolithotomy. a double-blind, placebo-controlled randomized clinical trial.

NCT ID: NCT04352153 Recruiting - Hyperuricemia Clinical Trials

Role of Uralyt-U in Patients With Hyperuricemia

Start date: April 1, 2020
Phase: N/A
Study type: Interventional

The purpose of the study is to provide a more direct and objective basis for the widespread use of potassium sodium hydrogen citrate granules in the treatment of uric acid stones.

NCT ID: NCT04346485 Recruiting - Urolithiasis Clinical Trials

Comparison of SP TFL and Ho:YAG for RIRS Using 145 µm and 200 µm Fibers

Start date: March 13, 2020
Phase: N/A
Study type: Interventional

The authors hypothesize that the RIRS using 150-microm Tm-fiber laser is superior than fiber with larger diameters, as 200-microm Tm-fiber laser or 200-microm holmium fiber laser, in such points as follows: - decreasing surgery time and laser-on time due to possibility of 4.3 fold ablation efficacy increase, which has been shown by Andreeva et al.; - increasing the flexible ureteroscope tip deflection lower pole stones availability; - decreased risk of complications and a better irrigation and visualization due to better irrigation with smaller fiber; - increasing of lithotripsy efficacy and laser beam density by lowering of beam focal spot due to using of lesser fiber diameter

NCT ID: NCT04286152 Recruiting - Nephrolithiasis Clinical Trials

Mirabegron And Ureteral Stent-related Pain (MAP) Trial

MAP
Start date: February 3, 2020
Phase: Phase 3
Study type: Interventional

Ureteric stents are used often following ureteroscopy for prevention of obstruction from edema and/or stone fragments. Up to 75% of patients experience pain following stenting, as well as lower urinary tract symptoms (LUTS) such as finding blood in the urine, voiding often, the need to urinate quickly resulting in a significant source of morbidity. The negative impact of stents results in a significant impact on health related quality of life. There is no standard of care for managing ureteric stent pain and lower urinary tract symptoms following surgery. A combination of α-blockers, antimuscarinics, acetaminophen, nonsteroidal anti-inflammatory drugs and opioids are currently the mainstay for treatment of post-operative pain and LUTS following stenting. Mirabegron is a beta-agonist that mediate relaxation of the detrusor muscle and has been useful in treating overactive bladder (OAB) which has similar symptoms to patients with an ureteric stent in place. Our goal is to assess if mirabegron can improve symptoms and decrease the need for additional pain medications. The investigators hypothesize that Mirabegron is effective in decreasing ureteral stent related LUTS and pain.

NCT ID: NCT04234035 Recruiting - Emergencies Clinical Trials

Shared Decision-Making for the Promotion of Patient-Centered Imaging in the ED: Suspected Kidney Stones

ED-KSS
Start date: December 11, 2019
Phase: N/A
Study type: Interventional

Although a CT scan is required for some Emergency Department patients with signs and symptoms of a kidney stone, recent evidence has shown that routine scanning is unnecessary and may expose young patients to significant cumulative radiation, increasing their risk of future cancers. Shared Decision-Making may facilitate diagnostic imaging decisions that are more inline with patients' values and preferences. By comparing a shared approach to diagnostic decision-making to a traditional, physician-directed approach, this study lays the foundation for a future randomized trial that will reduce radiation exposure, improve engagement, and improve the quality and patient-centeredness of Emergency Department care.

NCT ID: NCT04069013 Recruiting - Kidney Diseases Clinical Trials

Standard vs Mini-PCNL for the Treatment of Stone Disease

Start date: May 1, 2022
Phase: N/A
Study type: Interventional

Randomized comparison of patient outcomes following standard PCNL versus mini-PCNL.

NCT ID: NCT03995758 Recruiting - Kidney Calculi Clinical Trials

MOSES Lithotripsy Technology Applied to Stone Fragmentation During Ureteroscopy

Start date: June 6, 2019
Phase: N/A
Study type: Interventional

To determine if the effects of MOSES laser modulation technology can improve the safety and efficiency to laser fragmentation resulting in decreased total laser time, reduced potential for injury to the patient, and total OR time and utilization.

NCT ID: NCT03951558 Recruiting - Nephrolithiasis Clinical Trials

Comparison of the Impact of Diet vs Thiazide in BMD in Children With Idiopathic Hypercalciuria

HIC
Start date: May 11, 2018
Phase: N/A
Study type: Interventional

The investigator's objective is to compare and evaluate the impact of nutritional treatment vs. pharmacological treatment (hydrochlorothiazide) in bone mineral density in children with idiopathic hypercalciuria. A randomized, open-label, one-year follow-up study will be conducted in children aged 5 to 21 years with a confirmed diagnosis of idiopathic hypercalciuria or lithiasis, excluding those patients with secondary hypercalciuria (primary hyperoxaluria, treatment with vitamin D, Bartter syndrome, primary hyperparathyroidism), previous kidney transplantation. The impact of diet (hyposodic, calcium intake according to DIR for age, normal protein intake and high water intake) will be evaluated vs. the pharmacological treatment (hydrochlorothiazide) on bone mineral density.