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Urolithiasis clinical trials

View clinical trials related to Urolithiasis.

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NCT ID: NCT06331546 Recruiting - Healthy Clinical Trials

Gut Oxalate Absorption in Calcium Oxalate Stone Disease

Start date: April 1, 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial study is to test if patients with idiopathic calcium oxalate kidney stones have an increased absorption of dietary oxalate, which would lead to increased urinary excretion of oxalate. The study will recruit adult patients with a history of calcium oxalate kidney stones and healthy volunteers without kidney stones. Participants will - ingest fixed diets containing low and moderately high amounts of oxalate for 5 days at a time - ingest a soluble form of oxalate and sugar preparations to test gut permeability - collect urine, blood, stool and breath sample during the fixed diets and the soluble oxalate test

NCT ID: NCT06330246 Recruiting - Urolithiasis Clinical Trials

O. Formigenes Colonization in Calcium Oxalate Kidney Stone Disease

Start date: April 1, 2024
Phase: N/A
Study type: Interventional

The goal of this trial is to test if colonization with the gut bacteria Oxalobacter formigenes leads to a reduction in urinary oxalate excretion in patients with calcium oxalate kidney stone disease. The study will recruit adult participants with a history of calcium oxalate kidney stones who are not colonized with Oxalobacter formigenes. Participants will - ingest fixed diets containing low and moderately high amounts of oxalate for 4 days at a time - collect urine, blood and stool samples during the fixed diets - ingest a preparation of live Oxalobacter formigenes to induce colonization with Oxalobacter formigenes

NCT ID: NCT06306222 Recruiting - Kidney Stone Clinical Trials

Thulium Fiber Laser vs. Holmium:YAG Laser for the Ureteroscopic Treatment of Patients With Urinary Stone Disease

Start date: November 23, 2023
Phase: N/A
Study type: Interventional

This is a randomized controlled trial which aims to compare the efficacy and safety of Thulium fiber laser (TFL) and holmium:yttrium-aluminum-garnet (Ho:YAG) laser ablation during the treatment of upper urinary tract stone disease with flexible ureteroscopy, demonstrating clinical superiority of TFL.

NCT ID: NCT06269783 Recruiting - Urolithiasis Clinical Trials

Dual-process Mechanisms of Action for sipIT Intervention Effects in Patients With Urolithiasis

Start date: January 10, 2024
Phase: N/A
Study type: Interventional

The purpose of this study is to clarify the fundamental processes underlying behavior change, maintenance, and adherence during and after a 3-month fluid intake intervention period.

NCT ID: NCT06211842 Completed - Urolithiasis Clinical Trials

Genetic Variations That Increase the Risk for Calcium Kidney Stones: a Family-based Study

Start date: October 12, 2016
Phase:
Study type: Observational

Many things, like not drinking enough fluids, contribute to making kidney stones and there is also a genetic tendency. We looked into this in 1998-2000 in 14 families with several stone-formers. In four of these the risk for stones was passed down through one line of the family. We have now had a close look at the DNA of 47 members of these four families using a very sensitive technique called exome sequencing. We wanted to see if these individuals had inherited any rare changes (variations) in their DNA which would add to their risk of making stones. We found 11 variations which might be important. Surprisingly, these were not in genes which have been regarded as the main causes of stones. Most of them are unfamiliar to clinicians and scientists world-wide. Experts on the genes gave us helpful advice about the likely significance of the variations. Researchers in Paris, Lille and the UK (Oxford, Cambridge and Sheffield) did analyses to help to decide this. An exciting finding was that one of the variants, not previously identified in stone formers, had just been found in a large Italian family with stones. This small study has shown that: variations in a wide range of genes may contribute to stone formation; these occur in genes that we have not come across before; further laboratory studies are essential to investigate potentially important variants; sharing findings between laboratories doing similar studies world-wide is crucial.

NCT ID: NCT06176469 Recruiting - Urolithiasis Clinical Trials

Renal Colic and Urolithiasis in Poland

POLSTONE
Start date: December 1, 2023
Phase:
Study type: Observational

The aim of this study is to analyze the prevalence, effect on quality of life, and treatment-related behaviors for renal colic and urolithiasis in a population-representative sample of Poles. We will be using an Internet interview format for renal colic and urolithiasis evaluation. The study will include respondents representative for age and place of residence with adequate proportions of respondents from urban and rural areas.

NCT ID: NCT06158620 Not yet recruiting - Post Operative Pain Clinical Trials

Intra-nasal Ketorolac for Acute Ureteral Stent-associated Pain Following Ureteroscopy for Stone Disease

Start date: May 1, 2024
Phase: Phase 1/Phase 2
Study type: Interventional

Objective: To improve quality-of-life and health care delivery to patients receiving ureteral stents. Specific Aims: Evaluate the feasibility, practicality, and qualitative outcomes of utilizing intra-nasal ketorolac in patients with indwelling ureteral stents (Phase I), followed by a randomized trial comparing two non-steroidal anti-inflammatory drugs, intra-nasal Ketorolac versus oral Diclofenac. Hypotheses: Due to its favorable pharmacokinetics in relieving acute pain, investigators expect improved pain scores and a lower rate of unplanned clinical encounters in patients receiving intra-nasal ketorolac compared to those taking oral diclofenac following ureteroscopic surgery for urolithiasis. Study Rationale: Following ureteroscopic management of urolithiasis, patient with indwelling ureter stents have higher levels of discomfort compared to those without a ureter stent. Prior studies showed that intramuscular Ketorolac at time of ureter stent removal decreased the incidence of unplanned clinical encounters. Furthermore, onset of analgesic effect by intra-nasal ketorolac is faster than its oral form, and similar its intramuscular and intravenous counterparts.

NCT ID: NCT06152666 Recruiting - Bladder Cancer Clinical Trials

Day-case Endourology; Enablers, Barriers, Unexpected Outcomes

Start date: December 1, 2023
Phase:
Study type: Observational

A qualitative research study conducted in hospitals across England, in which staff members will be interviewed. We will interview staff who are directly or indirectly involved in delivering care for patients undergoing the operations of interest; namely bladder tumour resection, prostate resection or enucleation, and ureteroscopy for upper urinary tract stones. We hope to find out the reasons why some hospitals can perform day-case surgery with very high rates, and why others do not. We also hope to find out about any unexpected outcomes observed when performing day-case surgery for the operations of interest. Staff working in a range of different hospitals from across England with varying day-case rates will be interviewed. Hospitals in large city and more rural areas will be assessed. Interviews are anticipated to take place over a six month period. The study will end when "saturation" is achieved, whereby no new themes are identified through interviews. Saturation will be sought for each individual operation of interest.

NCT ID: NCT06144372 Completed - Urolithiasis Clinical Trials

Extracorporeal Shockwave Lithotripsy, Electroconductive and Electrohydraulic Types

Start date: March 31, 2022
Phase: N/A
Study type: Interventional

To evaluate the efficacy and safety of electroconductive (EC) and electrohydraulic (EH) extracorporeal shock wave lithotripsy (ESWL) for the treatment of ureter and kidney stones, this study conducted a randomized controlled trial.

NCT ID: NCT06092203 Recruiting - Pediatric ALL Clinical Trials

Quality of Life for Pediatric Urolithiasis

Elattar
Start date: February 1, 2023
Phase:
Study type: Observational [Patient Registry]

The aim of this study is to assess the quality of life (QoL) in pediatric patients with urinary stone disease.