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Nausea clinical trials

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NCT ID: NCT03125811 Completed - Nausea Clinical Trials

Value of Ondansetron Medication vs Inhaled Isopropyl Therapy in the Emergency Department (VOMIITED)

VOMIITED
Start date: July 17, 2017
Phase: Early Phase 1
Study type: Interventional

This study will compare two different ways to relieve nausea and vomiting in the Emergency Department. The usual treatment for nausea/vomiting is a drug called Zofran, but new studies have suggested that smelling alcohol pads can also help to relieve nausea and vomiting.

NCT ID: NCT03118986 Recruiting - Nausea Clinical Trials

RCT of Olanzapine for Control of CIV in Children Receiving Highly Emetogenic Chemotherapy

Start date: August 10, 2017
Phase: Phase 2
Study type: Interventional

Chemotherapy-induced nausea and vomiting (CINV) are among the most bothersome symptoms during cancer treatment according to children and their parents. Most children receiving highly emetogenic chemotherapy (HEC), including those receiving hematopoietic stem cell transplant (HSCT) conditioning, experience CIV despite receiving antiemetic prophylaxis. Olanzapine improves CINV control in adult cancer patients, has a track record of safe use in children with psychiatric illness, does not interact with chemotherapy and is inexpensive. We hypothesize that the addition of olanzapine to standard antiemetics will improve chemotherapy-induced vomiting (CIV) control in children receiving highly emetogenic chemotherapy

NCT ID: NCT03100669 Completed - Postoperative Pain Clinical Trials

Implementing a Postoperative MIRP (Minimally Invasive Repair of Pectus) Program Via Tele-monitoring

Start date: May 1, 2017
Phase:
Study type: Observational [Patient Registry]

MIRP (Minimally Invasive Repair of Pectus) as surgical correction of pectus excavatum or carinatum is performed to achieve physiological, cosmetic, and psychological benefits for the patient. Surgery is often associated with severe postoperative pain. In this study the researchers want to registrate pain, sleep, nausea/vomiting, and daily activities in short and long term follow up.

NCT ID: NCT03088696 Recruiting - Nausea Clinical Trials

Evaluation of PC 6 "Neiguan" With Conventional Acupuncture to Prevent PONV After Laparoscopic Cholecystectomy.

Start date: February 1, 2018
Phase: N/A
Study type: Interventional

Assessment of the effectiveness of PC 6 "Neiguan" with conventional acupuncture for preventing PONV (PostOperative Nausea and Vomiting) after laparoscopic surgery.

NCT ID: NCT03076411 Completed - Nausea Clinical Trials

Pepsin in Patients With Functional Dyspepsia

Start date: January 11, 2012
Phase: N/A
Study type: Observational

This non-interventional, observational study investigates the course of symptoms in patients with functional dyspepsia under treatment with a fixed combination of pepsin and amino acid hydrochloride over a period of approximately 6 weeks. The change of the Gastrointestinal Symptom Score (GIS©) was the primary parameter for the assessment of efficacy and was performed at baseline, after 3 and 6 weeks of treatment respectively. Safety measures included recording of AEs and physical examination as well as measurement of vital signs. The aim was to observe 100 patients during the course of this non-interventional study.

NCT ID: NCT03075163 Terminated - Nausea Clinical Trials

Post-Operative Therapy for Nausea or Vomiting

Start date: October 18, 2016
Phase: Phase 4
Study type: Interventional

This is a single site, prospective, randomized controlled study designed to evaluate the impact of acupressure when used as an initial treatment before rescue medications in the treatment of post-operative nausea and/or vomiting at UCD.

NCT ID: NCT03061396 Recruiting - Clinical trials for Chemotherapy-induced Nausea and Vomiting

The Comparative Study on the Efficacy and Safety of Single Acupoint and Matching Acupoints

Start date: February 17, 2017
Phase: N/A
Study type: Interventional

The purpose of this study is to clarify whether the matching acupoints are more effective than a single point by electro-acupuncture in the management of chemotherapy-induced nausea and vomiting.

NCT ID: NCT03060746 Completed - Weight Loss Clinical Trials

Helicobacter Pylori Sample Collection Protocol Pre Therapy Subjects

Start date: February 14, 2017
Phase:
Study type: Observational

The primary objective is to obtain stool samples from pre-therapy subjects already undergoing evaluation for an H. pylori infection by upper esophagogastroduodenoscopy (EGD) and gastric biopsy.

NCT ID: NCT03060733 Completed - Weight Loss Clinical Trials

Helicobacter Pylori Sample Collection Protocol Post Therapy Subjects

Start date: February 14, 2017
Phase:
Study type: Observational

The primary objective is to obtain stool samples from post-therapy subjects already undergoing evaluation for an H. pylori infection by upper esophagogastroduodenoscopy (EGD) and gastric biopsy.

NCT ID: NCT03045133 Completed - Pain, Postoperative Clinical Trials

QUALITY OF RECOVERY AFTER INTRAOPERATIVE MORPHINE OR METHADONE

Start date: June 20, 2016
Phase: Phase 4
Study type: Interventional

Introduction. Despite the advantages associated with the use of remifentanil during total intravenous anesthesia (TIVA), it has been observed a frequent difficulty in the control of postoperative pain due to the risk of developing hyperalgesia and acute tolerance associated with the administration of this opioid. There is evidence that NMDA receptors are involved in the development of these changes. Methadone is an opioid that exhibits analgesic potency similar to that of morphine but has NMDA antagonist activity and longer duration of action as additional features. The objective of the study was to evaluate the quality of recovery (QoR40) of patients undergoing TIVA for laparoscopic cholecystectomy and who received morphine or methadone to control postoperative pain. Methods. Patients aged 18 to 65 years, physical status ASA I and II, submitted to total venous anesthesia (propofol and remifentanil) for laparoscopic cholecystectomy and eligible to participate in this prospective and randomized clinical study will be evaluated. After induction of anesthesia, patients will receive a solution containing 0.1 mg.kg-1 morphine (MF group) or 0.1 mg.kg-1 methadone (MT group). Data on the presence of pain, nausea, vomiting, tremor, drowsiness, presence of SpO2 <92%, even with O2 face mask (5 L.min-1) and length of stay will be recorded at PACU. The pain will be evaluated every 15 minutes on a verbal numerical scale (ENV) from 0 to 10. E.v. morphine 0.1 mg.kg-1 (MF group) or methadone 0.1 mg.kg-1 (MT group) will be administered every 15 minutes to obtain the score below 3. After discharge from the PACU, all patients will receive intravenous ketoprofen every 12 hours and dipyrone every 6 hours. For cases where the patient considers the analgesic regimen insufficient, tramadol (100 mg) will be administered intravenously at 8-hour intervals. The consumption of analgesics, the intensity of pain, the occurrence of nausea, vomiting and other complications in the ward will be recorded. The application of the questionnaire (QoR40) will be performed in the ward the morning after the surgery by a medical student.