Myocardial Ischemia & Transfusion

Status Completed

Clinical Trial Summary

The purpose of this study is to compare two red blood cell transfusion strategies (liberal and restrictive) for patients who have had an acute myocardial infarction and are anemic.

Clinical Trial Description

In most clinical settings, evidence suggests it is safe to wait to give a blood transfusion. However, for those who have suffered a heart attack, there is a lack of high quality evidence to guide transfusions. This 3500 subject multi-center randomized trial will fill that void. Hospital inpatients diagnosed with myocardial infarction who have blood counts less than 10 g/dL are randomized to receive either a liberal or a restrictive transfusion strategy. Patients randomized to the liberal transfusion strategy will receive a red blood cell transfusion anytime there is a blood count of less than 10 g/dL. Patients randomized to the restrictive transfusion strategy are permitted to receive a blood transfusion if the blood count is below 8 g/dL and the physician believes it is in the patient's best interest. A transfusion will be strongly recommended if the blood count drops to less than 7 g/dL. If the patient has symptoms of angina (e.g., chest discomfort described as pressure or heaviness) that do not go away with medication, a blood transfusion is ordered regardless of the blood count. The transfusions strategies will be maintained until hospital discharge for a maximum of 30 days. Patients will be followed for 30 days for clinically relevant outcomes. Vital status will be confirmed at 180 days. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02981407
Study type	Interventional
Source	Rutgers, The State University of New Jersey
Contact
Status	Completed
Phase	Phase 3
Start date	April 25, 2017
Completion date	October 20, 2023

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Myocardial Ischemia and Transfusion — MINT

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms