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Utilization of Diagnostic Ultrasound in the Detection and Therapy of Acute Coronary Syndromes

Myocardial Infarction Clinical Trial

Official title:
Utilization of Diagnostic Ultrasound in the Detection and Therapy of Acute Coronary Syndromes

Clinical Trial Summary

The study will see if mechanical impulses delivered by an echocardiographic probe during a continuous infusion of MRX 801 are capable of improving blood flow in smaller heart vessels in patients with acute coronary syndromes.

Clinical Trial Description

Pre-clinical studies have indicated that, during a continuous infusion of intravenous perfluorocarbon-containing microbubbles, the ultrasonic power delivered from a diagnostic ultrasound transducer is capable of restoring microcirculatory flow and improving epicardial recanalization rates following acute coronary thrombotic occlusions. Since both diagnostic ultrasound and intravenous infusions of microbubbles are a Class I indication to assess regional and global left ventricular function and risk area in patients with ST segment elevation myocardial infarction (STEMI), this pilot study will examine whether diagnostic assessments of left ventricular function and risk area size impacts epicardial recanalization rates and infarct size in STEMI. The aim of this study is to test whether guided high mechanical index impulses from a diagnostic transducer during a continuous infusion of intravenous microbubbles are capable of improving microvascular recanalization and epicardial recanalization rates in STEMI, as assessed by coronary angiography, and recovery of regional microvascular perfusion and function in the post-infarction period. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00955136
Study type Interventional
Source University of Nebraska
Contact
Status Withdrawn
Phase N/A
Start date July 2009
Completion date January 25, 2010
View Details
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