Myeloid-Related Protein in Evaluation of Acute Chest Pain in the Emergency Departement

Myocardial Infarction Clinical Trial

— MyRiAD  

Official title:

Study of Myeloid-related Protein 8/14 and Additional Biomarkers (Multi Marker Approach) for Early Diagnosis and Risk Stratification in Patients Presenting With Acute Chest Pain at the Emergency Department

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00657436
• Other study ID #: MyRiAD
• Status: Completed
• Phase: N/A
• First received: April 8, 2008
• Last updated: May 30, 2012
• Start date: March 2008
• Est. completion date: December 2010

Study information

• Verified date: May 2012
• Source: University of Zurich
• Contact: n/a
• Is FDA regulated: No
• Health authority: Switzerland: Federal Office of Public Health
• Study type: Observational

Clinical Trial Summary

The purpose of the study is the evaluation of multiple biomarkers related to acute coronary syndromes, including myeloid-related protein 8/14 (MRP 8/14), along with established clinical markers, for early diagnosis and risk stratification in patients presenting with acute chest pain at the emergency department.

Study hypothesis: MRP 8/14, alone or together with other established or new biomarkers, increases the earliness, sensitivity, and specificity of diagnosing acute coronary syndromes.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 403
• Est. completion date: December 2010
• Est. primary completion date: December 2010
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 90 Years

Eligibility

Inclusion Criteria:

• All patients in the emergency department of the University Hospital Zurich with measurement of troponin during the routine diagnostic evaluation.

Exclusion Criteria:

• Refusal or inability to give informed consent.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Acute Coronary Syndrome
• Chest Pain
• Coronary Artery Disease
• Coronary Occlusion
• Coronary Thrombosis
• Infarction
• Myocardial Infarction
• Myocardial Ischemia

Locations

Country	Name	City	State
Switzerland	Cardiology, University Hospital	Zurich

Sponsors (2)

Lead Sponsor	Collaborator
University of Zurich	Swiss National Science Foundation

Country where clinical trial is conducted

Switzerland, 

References & Publications (1)

Altwegg LA, Neidhart M, Hersberger M, Müller S, Eberli FR, Corti R, Roffi M, Sütsch G, Gay S, von Eckardstein A, Wischnewsky MB, Lüscher TF, Maier W. Myeloid-related protein 8/14 complex is released by monocytes and granulocytes at the site of coronary occlusion: a novel, early, and sensitive marker of acute coronary syndromes. Eur Heart J. 2007 Apr;28(8):941-8. Epub 2007 Mar 26. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Diagnosis of acute coronary syndrome		Emergency room and/or hospital stay	No
Secondary	Incidence of any acute coronary event		1 year	No
Secondary	Morbidity from coronary artery disease		1 year	No
Secondary	Mortality		1 year	Yes