Myocardial Infarction Clinical Trial
The purpose of this study is to determine whether intracoronary transfer of autologous bone
marrow cells can induce angiogenesis, subsequently improving regional myocardial perfusion,
and finally resulting in improved systolic and diastolic left ventricular function in
patients with myocardial infarction.
50 patients with stable left ventricle function will - with six months interval - receive
two treatments with bone marrow transplantation intracoronary in vessels supplying
dysfunctional myocardial territories and Coronary Artery Bypass Graft (CABG).
This research study is being performed to find out more information about the safety and
efficacy of autologous bone marrow stem cells transplantation. In patients with myocardial
infarction, the heart muscle does not pump well. Over a period of years, this continues to
get worse until the patient dies of heart failure. The researchers are trying to find out if
the transplantation of these stem cell can make a change in the functioning of these areas
of the heart muscle.
Patients between 18 and 70 years of age who received autologous bone marrow stem cell
transplant at the Fuwai cardiovascular hospital may be eligible for this study. Candidates
must have had their first transplant at least 3 years before entering the current study.
These patients receive autologous bone marrow cells transplantation intracoronary undergoing
Coronary Artery Bypass Graft. The objective evaluations will be performed at baseline and
during 6 months follow-up.
Heart function tests may include the following:
1. Electrocardiogram (EKG) evaluates the electrical activity of the heart. Electrodes
placed on the chest transmit information from the heart to a machine.
2. Echocardiogram (Echo) is an ultrasound test that uses sound waves to create an image of
the heart and examine the function of the heart chambers and valves.
3. Gated acquisition scan is a nuclear medicine test that uses a small amount of
radioactive chemical injected into a vein. A special scanner creates an image of the
heart for examining the beating motion of the muscle.
4. MRI evaluates function of the heart chambers the beating motion of the muscle.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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