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Clinical Trial Summary

This study will evaluate the evolution of leptomeningeal lesions via leptomeningeal contrast enhancement (LMCE) presence/disappearance after treatment administration in patients with active progressive multiple sclerosis (MS). In addition, this study will investigate if the presence of leptomeningeal inflammation is associated with alterations of B cell repertoire and whether therapy with ocrelizumab will lead to change of B cell repertoire in LMCE-positive patients.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05208840
Study type Interventional
Source Hoffmann-La Roche
Contact Reference Study ID Number: ML42302, https://forpatients.roche.co
Phone 888-662-6728
Email [email protected]
Status Recruiting
Phase Phase 4
Start date February 14, 2023
Completion date January 31, 2026

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