Bright Light Therapy as Possible Treatment Option for MS-Fatigue

Multiple Sclerosis Clinical Trial

Official title: Bright Light Therapy as Possible Treatment Option for Fatigue in Multiple Sclerosis Patients - A Randomised Controlled Trial

Status Recruiting

Clinical Trial Summary

This study aims to investigate the effect of a 2-week trial of bright light therapy (BLT, 10.000 lx) on fatigue in multiple sclerosis (MS) patients. In this randomised placebo-controlled trial, the effect of bright light therapy will be compared to dim red light. MS-fatigue is quantified by patients using a visual analogue scale (VAS) and activity levels, subjective and objective sleep parameters and daytime sleepiness are measured.

Clinical Trial Description

Materials and methods:

• visual analogue scale (4x/day for 6 weeks; measuring fatigue)

• wrist actigraphy (6 weeks)

• sleep diaries (6 weeks)

• polysomnography (2x)

• multiple sleep latency test (2x)

• 4 subtests of the TAP (Testbatterie zur Aufmerksamkeitsprüfung; Alertness, Vigilance, Go/No-Go, Split Attention)

• questionnaires (Fatigue Severity Scale, Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, Beck Depression Inventory, Beck Anxiety Inventory, Modified Fatigue Impact Scale, Morningness-Eveningness Questionnaire) ;

Related Conditions & MeSH terms

• Fatigue
• Multiple Sclerosis
• Sclerosis

• NCT number: NCT04681586
• Study type: Interventional
• Source: Medical University of Vienna
• Contact: Stefan Seidel, MD
• Phone: 0043 1 40 400 34280
• Email: stefan.seidel@meduniwien.ac.at
• Status: Recruiting
• Phase: N/A
• Start date: December 1, 2019
• Completion date: January 2022