Multiple Sclerosis Clinical Trial
— CTSMOfficial title:
Neurophysiological, Dynamometric, Functional and Clinical Assessment of the Cross-Training Effect in Patients With Multiple Sclerosis
Verified date | March 2017 |
Source | Università degli Studi di Sassari |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The purpose of this study is to determine whether, in patients with multiple sclerosis presenting with marked asymmetry of strength, training the less-affected limb with a Cross-Training approach may induce a meaningful transfer of strength with neurophysiological, functional and clinical correlates, to the contralateral, more-impaired limb.
Status | Completed |
Enrollment | 45 |
Est. completion date | March 27, 2017 |
Est. primary completion date | March 27, 2017 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 65 Years |
Eligibility |
Inclusion Criteria: - Age: 18-65 years - Expanded Disability Status Scale (EDSS) =6 (Pyramidal functional system =3) Exclusion Criteria: - Clinically relevant cognitive disorders; - Disability caused by other diseases; - Medication with corticosteroids within three months prior to enrolment; - Medication with botulinum toxin within six months prior to enrolment; - Clinically or radiologically documented exacerbation within six months prior to enrolment; - Variations in disease-modifying drugs (DMD) within three months prior to enrolment; - Severe ataxia and postural instability (assessed with Berg Balance Scale); - Depression |
Country | Name | City | State |
---|---|---|---|
Italy | Department of Biomedical Sciences- University of Sassari | Sassari | Sassari (SS) |
Italy | Department of Clinical and Experimental Medicine, University of Sassari | Sassari | |
Italy | Department of Surgery, Microsurgery and Medical-Surgical Specialties | Sassari |
Lead Sponsor | Collaborator |
---|---|
Università degli Studi di Sassari |
Italy,
Manca A, Pisanu F, Ortu E, De Natale ER, Ginatempo F, Dragone D, Tolu E, Deriu F. A comprehensive assessment of the cross-training effect in ankle dorsiflexors of healthy subjects: A randomized controlled study. Gait Posture. 2015 Jun;42(1):1-6. doi: 10.1 — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Walking performance | Regarding the clinical and functional relevance to MS patients, changes from baseline in walking performance will be assessed through 6-Minute Walking Test (6MWT), which has been demonstrated to be a feasible, reproducible and reliable measure in MS and to be strongly correlated to subjective measures of ambulation; 10 Meter-Walk Test (10MWT), which estimates the walking speed at both comfortable and maximal velocities. | It will be assessed at baseline, within one week from the completion of the 6-week rehabilitation phase and at 12-week follow up. | |
Other | Fatigue | Modified Fatigue Impact Scale (MFIS): extracted from the Multiple Sclerosis Quality of Life Inventor. It consists of 21 items and provides an assessment of the effects of fatigue in terms of physical, cognitive, and psychosocial functioning. | Assessment at baseline, within one week from the completion of the 6-week rehabilitation phase and at 12-week follow up. | |
Other | Executive functions | Frontal Assessment Battery (FAB): it tests executive functions, in a form of an interview with 6 functional tasks covering 5 domains: memory, planning, attention, reflex and visual spatial. The FAB correlates with dysfunction in a variety of cognitive domains including attention, memory, and executive functions. | Assessment at baseline, within one week from the completion of the 6-week rehabilitation phase and at 12-week follow up. | |
Other | Spasticity symptom severity | Modified Ashworth Scale: it is a widely used qualitative scale for the assessment of spasticity symptom severity and measures resistance to passive stretch, scoring from 0 (no increase in tone) to 4 (affected parts rigid in flexion or extension). | Assessment at baseline, within one week from the completion of the 6-week rehabilitation phase and at 12-week follow up. | |
Other | Gait Analysis for patients with Multiple Sclerosis | At baseline and post-intervention | ||
Primary | Muscular strength | Strength changes in the weaker side compared to the contralateral, through isokinetic dynamometry. | Muscular strength will be assessed at baseline, within one week from the completion of the 6-week rehabilitation phase and at 12-week follow up. | |
Secondary | Neural adaptations to Cross Training | Neural adaptations to CT occurring at cortical and/or spinal level, through transcranial magnetic stimulation (TMS) and peripheral electrophysiological recordings. | Neural adaptations will be assessed at baseline, within one week from the completion of the 6-week rehabilitation phase and at 12-week follow up. |
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