Changes in Ingestive Behaviour Following Gastric Bypass

Status Completed

Clinical Trial Summary

The gastric bypass procedure is known to be one of the most successful treatments for morbid obesity and Type 2 diabetes mellitus, and has been shown to decrease appetite, energy intake, body weight and glycemia both in the short and long term. A number of reports hypothesise that these changes may be driven, at least in part, by positive shifts in food preferences following surgery. However, findings are drawn from self-reported dietary intakes which are beset with measurement bias, thus precluding definite conclusions. The current work aims to directly observe food intake to test the hypothesis that after gastric bypass food intake changes in a manner which leads to beneficial outcomes on body weight when compared to weight stable control participants. Patients (n=32) with a planned gastric bypass procedure will be recruited from Phoenix Health (Ireland and England) and Letterkenny University Hospital (Ireland), alongside control participants (n=32) with no planned weight loss. All subjects will attend the Human Intervention Studies Unit (HISU), Ulster University on five occasions (1-month pre-surgery and 3, 12, 24 and 60 months post-surgery, with controls being time-matched). Study visits will be fully residential involving two overnight stays within the facility during which participants' 24-hour food intake will be covertly measured (7am-11pm Day 2 and breakfast Day 3) and the following procedures undertaken; basal metabolic rate, body composition, bone health, assessment of liking/wanting high fat foods and post-meal gut hormone responses. On each study visit participants will have ad lib access to a range of foods of varying macronutrient composition and which are compatible with their stated food preferences (assessed prior to the start of the study). Changes in all ingestive behaviours will be evaluated over time as compared to the control participants.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03113305
Study type	Observational
Source	University of Ulster
Contact
Status	Completed
Phase
Start date	September 1, 2016
Completion date	May 31, 2023

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03657927` - A Comparison of McGrath MAC Versus C-MAC Videolaryngoscopes in Morbidly Obese Patients	N/A
Recruiting	`NCT04934826` - Comparison of the Absorption of Hydrolyzed or Intact Proteins in Morbid Obese Patients After the Roux Y Gastric Bypass	N/A
Completed	`NCT03181347` - The Microbiology of Bariatric Surgery	N/A
Completed	`NCT03886870` - Obesity, Lifestyle and Work Intervention	N/A
Active, not recruiting	`NCT04433338` - The PREBA Study: Effect of Preoperative Weight Loss With a 14-day Low-calorie Diet on Surgical Procedure and Outcomes in Patients Undergoing RYGB Surgery	N/A
Completed	`NCT03553849` - Utilization of Very Low Calorie Diet in Obese General Surgery Patients	N/A
Completed	`NCT05854875` - Diabetes Remission After RYGBP and RYGBP With Fundus Resection	N/A
Not yet recruiting	`NCT03203161` - Registry on Obesity Surgery in Adolescents
Not yet recruiting	`NCT03601273` - Bariatric Embolization Trial for the Obese Nonsurgical	Phase 1
Recruiting	`NCT02129296` - Intragastric Balloon, Air Versus Fluid Filled: Randomized Prospective Study	Phase 1/Phase 2
Active, not recruiting	`NCT01564732` - Multicenter Prospective Randomized Controlled Trial of Plicated Laparoscopic Adjustable Gastric Banding	N/A
Completed	`NCT02033265` - Ultrasound-Guided Axillary Brachial Plexus Block: Influence of Obesity
Not yet recruiting	`NCT01652105` - Randomized Trial of Preoperative Diets Before Bariatric Surgery	N/A
Completed	`NCT01963637` - Gastric Volumetry by Gastric Tomodensitometry With Gas	N/A
Terminated	`NCT01759550` - Prospective Case-Series of Ligasure Advance Pistol Grip and LigaSure Blunt Tip
Completed	`NCT01955993` - Fentanyl Metabolism in Obese Adolescents	N/A
Completed	`NCT01149512` - Outcomes of the Adjustable Gastric Band in a Publicly Funded Obesity Program	N/A
Recruiting	`NCT01685177` - Single Anastomosis Duodeno-Ileal Bypass vs Standard Duodenal Switch as a Second Step After Sleeve Gastrectomy in the Super-Morbid Obese Patient	N/A
Completed	`NCT02414893` - Hunger/Satiety's Physiopathologic Study in Morbidly Obese Patients	N/A
Completed	`NCT01675713` - Lifestyleintervention for the Treatment of Severe Obesity	N/A