Effect of Number of Meals on Metabolism After Weight Loss Surgery — LAF 28  

Morbid Obesity Clinical Trial

Official title: Effect of Number of Meals on Metabolism After Weight Loss Surgery

Status Completed

Clinical Trial Summary

The purpose of this study is to determine the effect of meal size and texture on the levels of incretin hormone, GLP-1, after Gastric Bypass Surgery (GBP). Patterns of food intake change after bariatric surgery and patients often eat multiple small low-calorie meals, a pattern that may affect blood glucose as well as incretin levels. Whether the release of GLP-1 after an oral challenge or a single liquid meal has any physiological relevance in 'real life' setting of multiple small meals diet is unclear.

Clinical Trial Description

The main goal is to study the effect of meal size and texture on incretin levels after GBP. Patients will be studied before GBP (T0) and 12-15 months after GBP (T1). At T0 and T1, patients will come for 2 study days for 8 hours: On one study day, a single meal will be served, on the second study day, three small meals, with the order of the conditions randomly assigned. The total amount of calories (600 kcal) and the over all nutrient composition (55% CHO, 15 % protein, 30% fat) will be equivalent between conditions. The meals will be either all solid or all liquid. Patients enrolled in the study will be randomly assigned to solid or liquid test meals.

Recruitment and data gathering for this study were performed at St. Luke's Hospital in New York, NY. Data Analysis was performed at Columbia University Medical Center in New York, NY. ;

Related Conditions & MeSH terms

• Morbid Obesity
• Obesity, Morbid
• Weight Loss

• NCT number: NCT02929212
• Study type: Interventional
• Source: Columbia University
• Status: Completed
• Phase: N/A
• Start date: September 2009
• Completion date: April 2014