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Mitral Valve Disease clinical trials

View clinical trials related to Mitral Valve Disease.

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NCT ID: NCT04464876 Active, not recruiting - Clinical trials for Mitral Regurgitation

SATURN Transcatheter Mitral Valve Replacement for Functional Mitral Regurgitation

Start date: August 19, 2020
Phase: N/A
Study type: Interventional

This study is a prospective, single-arm, multi-center feasibility clinical study of the SATURN TA System for the treatment of NYHA Class ≥ II patients with severe functional mitral regurgitation who are not suitable for surgical treatment following Heart Team assessment.

NCT ID: NCT04408430 Recruiting - Clinical trials for Mitral Regurgitation

The MITRAL II Pivotal Trial (Mitral Implantation of TRAnscatheter vaLves).

MITRAL-II
Start date: March 8, 2021
Phase: N/A
Study type: Interventional

A prospective multicenter study enrolling high surgical risk patients with severe mitral annular calcification (MAC) and symptomatic mitral valve dysfunction (severe stenosis, ≥ moderate to severe regurgitation, or mixed ≥ moderate stenosis and ≥ regurgitation). There are 2 Arms in this study: 1) "Transseptal (TS) Valve-in-MAC" (ViMAC) Arm, and 2) Natural History of Disease Registry (NHDR) for patients treated with medical treatment only (which includes patients who meet inclusion criteria but can't be treated with transeptal ViMAC due to the presence of anatomical exclusion criteria or other exclusion criteria) and have not had other procedures that may impact outcomes (i.e., alcohol septal ablation or radiofrequency ablation). The study also includes a Registry of Permanently Unassigned" for subjects who undergo preemptive septal ablation procedures (alcohol or radiofrequency) in anticipation of continuing onto ViMAC arm, but are not accepted in the ViMAC Study arm or the patient chooses not to undergo ViMAC procedure.

NCT ID: NCT04401397 Completed - Clinical trials for Coronary Artery Disease

Effect of Early Mobilization on Length of Stay, Recovery and Readmission Rate of Patients After CABG or AVR/MVR Surgery

Start date: June 3, 2020
Phase: N/A
Study type: Interventional

The present study will investigate the volume and extent of the expected physiological effects of "early mobilization" on the prevention of the clinical illness' detrimental sequelae and on the functional recovery promotion of CABG, AVR and MVR patients. Consequently, it will investigate if the improved health outcomes may limit the number and intensity of complications and thus if it may speed up hospital discharge.

NCT ID: NCT04235569 Completed - Clinical trials for Mitral Valve Disease

Warfarin Initiation in Mechanical Mitral Valve Replacement Patients

Start date: March 1, 2018
Phase: Phase 4
Study type: Interventional

A prospective, comparative study evaluating warfarin initiation in a dose of 3mg versus 5mg in mechanical mitral valve prostheses patients who received anticoagulation with warfarin with the use of enoxaparen as a bridging agent .Fifty patients were included and compared in terms of the primary outcome time to reach therapeutic INR range.Other outcomes includes proportion of patients who achieved the target INR of 2.0-3.0 between day 3 and day 5, total dose of enoxaparin required for bridging, safety related to both doses of anticoagulants used

NCT ID: NCT04231461 Recruiting - Clinical trials for Aortic Valve Stenosis

Quality of Life After Cardiac Surgery

QUACS
Start date: July 19, 2019
Phase:
Study type: Observational

During the last twenty years heart surgery has become safer and the number of patients having heart surgery has increased with more frail patients being offered increasingly complex surgery. Heart operations often improve survival and quality of life (QoL), but that is not true for all patients. Regarding survival, clinicians can measure the risk to life from having a heart operation and the risk to life from not quite precisely, but clinicians have little idea about the impact of heart operations on QoL, which is the outcome that patients care about most. Clinicians are unable to provide patients with robust information on how an operation will affect their QoL. This study will provide this information by analysing the data from patient questionnaires immediately before and after the procedure and monthly thereafter for 12 months.

NCT ID: NCT04190602 Recruiting - Clinical trials for Mitral Regurgitation

Multicenter Post-Market Observational Registry of the NeoChord Artificial Chordae Delivery System

AcChord
Start date: February 9, 2020
Phase:
Study type: Observational [Patient Registry]

The objective of this study is to evaluate the 5-year outcomes of participants with degenerative mitral valve disease treated with the NeoChord Artificial Chordae System, Model DS1000 in a post-market setting.

NCT ID: NCT04147884 Active, not recruiting - Clinical trials for Cardiovascular Diseases

A Feasibility Study of the Millipede Transcatheter Annuloplasty Ring System in Patients With Functional Mitral Regurgitation

Start date: November 13, 2019
Phase: N/A
Study type: Interventional

To evaluate the feasibility and safety of the Millipede Transcatheter Annuloplasty Ring System in subjects with functional mitral regurgitation

NCT ID: NCT04098328 Terminated - Clinical trials for Mitral Regurgitation

Early Feasibility EXperience of Posterior Leaflet RestOration to REduce Mitral Regurgitation

EXPLORE MR
Start date: January 1, 2020
Phase:
Study type: Observational [Patient Registry]

Early feasibility study, single-arm registry design

NCT ID: NCT04067635 Enrolling by invitation - Clinical trials for Mitral Regurgitation

Primary Mitral Regurgitation Repair

Start date: May 25, 2018
Phase:
Study type: Observational

This longitudinal cohort study evaluates the relationship of myocardial tissue markers characteristics assessed by cardiac MRI, with clinical measures of symptoms and functions in adults with primary mitral regurgitation. Participants are followed conservatively or may choose to undergo surgical repair at the discretion of their clinical team.

NCT ID: NCT04045340 Completed - Clinical trials for Mitral Valve Disease

Intraoperative Global Longitudinal Strain and Global Longitudinal Strain Rate as Predictors of Unfavorable Outcome in On-Pump Mitral Surgery

Mit-GO
Start date: October 28, 2019
Phase:
Study type: Observational

The aim of the present study is to assess the best echocardiographic parameters (GLS, GLS rate and standard echocardiographic parameters) predicting LCOS in on-pump mitral surgery.