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Mitral Valve Disease clinical trials

View clinical trials related to Mitral Valve Disease.

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NCT ID: NCT05193760 Completed - Clinical trials for Coronary Artery Disease

Robustness Check of Placement and Measurement Algorithms for Blood Flow Measurement on Common Carotid Artery

RAdiUS
Start date: October 6, 2021
Phase:
Study type: Observational [Patient Registry]

This study is set up to test the robustness of algorithms and models and to optimize them. Furthermore, data are used to investigate the influence of probe orientation on parameters of the common carotid artery.

NCT ID: NCT05076604 Recruiting - Clinical trials for Aortic Valve Disease

Effects of Microplegia on Transfusion Rates After Cardiac Surgery

Start date: March 25, 2019
Phase: Phase 4
Study type: Interventional

This is a prospective, randomized study that is studying the rate of red blood cell (RBC) transfusion rates after planned heart (cardiac) surgery. The study will be conducted at Barnes-Jewish Hospital. Cardioplegia refers to the method of stopping (arresting) the heart in order to perform heart surgery. However, cardioplegia has also come to refer to the solution to achieve cardiac arrest as well as the machinery in which to deliver the solution. This study will investigate our current Standard Cardioplegia (diluted 4:1 blood cardioplegia) versus Microplegia (undiluted blood cardioplegia) to determine if Microplegia reduces peri-operative blood transfusion rates as compared to Standard Cardioplegia. All forms of cardioplegia will be delivered using the MPS2 Microplegia delivery machine by Quest Medical, Inc. Patients will be randomized to receive undiluted microplegia or standard 4:1 cardioplegia. The patient and the surgeon will be blinded to the randomization. Patients will be followed for 30 days post-operatively (or until their initial standard of care post-operative follow up visit with cardiac surgery if that appointment falls outside of the 30 day post-operative window) for the development of any adverse events as well as documentation of blood products given. We will draw one tube of blood for troponin levels at four time points; 1 draw before surgery (this may be done during the intraoperative period), and 3 draws post-operatively: ICU arrival, 12 hours post-ICU arrival and 24 hours post-ICU arrival. This is to closely monitor the patient for any heart tissue injury.

NCT ID: NCT04954404 Recruiting - Clinical trials for Mitral Valve Disease

Transcatheter Mitral Valve InterventiOn Single Center Registry in CHinese Patients With Mitral Valve Disease (TORCH-M)

Start date: May 1, 2021
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the safety and effectiveness of transcatheter mitral valve intervention in Chinese population with mitral valve disease.

NCT ID: NCT04950192 Active, not recruiting - Stroke Clinical Trials

Philips Intracardiac Echocardiography (ICE) Clinical Registry

Start date: October 25, 2021
Phase:
Study type: Observational [Patient Registry]

The purpose of this observational registry is to report real-world safety and performance of VeriSight for ultrasound guided ICE imaging in percutaneous cardiac intervention procedures when used in standard clinical practice.

NCT ID: NCT04916535 Recruiting - Clinical trials for Mitral Valve Disease

Prospective Multicenter Study on Mitral Annular Disjunction

MAD-NesS
Start date: June 3, 2021
Phase: N/A
Study type: Interventional

Observational cohort prospective multicenter study on patients with mitral annular disjunction (MAD). MAD is defined as a separation (≥1 mm) between the atrial wall-mitral valvular junction and the left ventricular free wall during end-systole

NCT ID: NCT04914468 Recruiting - Clinical trials for Mitral Valve Disease

Hamburg TranscathEteR Mitral Valve REplacement RegiStry

HERMES
Start date: March 8, 2021
Phase:
Study type: Observational

The Hamburg TranscathEteR Mitral Valve REplacement RegiStry (HERMES) is a prospective clinical cohort registry aiming to gather follow-up information on short- and long-term outcome of patients with mitral valve disease that undergo transcatheter mitral valve replacement (TMVR) screening. In particular, long-term durability and function of implanted bioprosteses is of utmost interest for both patients and clinicians. Moreover, this study aimes to investigate and compare the different treatment strategies patients undergo after successful or unsuccessful screening for TMVR.

NCT ID: NCT04787757 Recruiting - Clinical trials for Heart Valve Diseases

Autonomous Robotics for Transcatheter Cardiac Procedures

ARTERY
Start date: March 15, 2021
Phase:
Study type: Observational

Cardiovascular diseases represent the most common cause of death worldwide. Percutaneous approaches with intravascular catheters are pivotal, since they allow to treat patients with high perioperative risks. However, catheter-based treatments require steep learning curves and are characterized by poor ergonomics and exposure to damaging radiation. ARTERY will offer a radiation-free approach based on shared-autonomy robotic catheters, with increased user engagement and easy interaction. Intraprocedural three-dimensional echocardiography as well as computed tomography images obtained during usual clinical practice will provide artificial intelligence algorithms that will turn catheter navigation to a simple task. Optical and electromagnetic sensing techniques will ensure a superior view upon the cardiovascular anatomy and will guide the autonomous catheter upon the interventionist supervision, who will be able to take over control at any instant.

NCT ID: NCT04736667 Recruiting - Clinical trials for Mitral Valve Disease

Mitral Valve Screening Survey

MVSS
Start date: August 6, 2021
Phase:
Study type: Observational [Patient Registry]

This study aims to examine the clinical profile/anatomical characteristics and natural history of patients who subsequently fail screening for transcatheter mitral valve intervention (TMVI).

NCT ID: NCT04717570 Active, not recruiting - Clinical trials for Mitral Valve Disease

Early Feasibility Study for the Foldax TRIA Mitral Heart Valve Replacement

FOLDAX
Start date: February 1, 2021
Phase: N/A
Study type: Interventional

The purpose of this study is to conduct the initial clinical investigation of the Foldax Polymer Mitral Valve to collect evidence on the device's safety and performance. The study is anticipated to confirm successful clinical safety and clinical effectiveness with significant improvements in clinical hemodynamic performance.

NCT ID: NCT04659655 Recruiting - Clinical trials for Aortic Valve Disease

VIenna Pilot Study for Automated Annular Suturing Technology

VIP-RAM
Start date: January 1, 2021
Phase: N/A
Study type: Interventional

The objective of this study is to compare surgical outcomes between patients who underwent valve replacement with and without the help of the automated annular suturing technology. In addition, data of the early and intermediate postoperative period will be collected within routine clinical follow-up in order to assess morbidity and mortality as well as echocardiographic parameters.