Coronary Artery Disease Clinical Trial
Official title:
Interplay of miRNA-146a and miRNA-126 in Chronic Periodontitis Patients With Coronary Artery Disease
The role of micro-RNAs in chronic periodontitis associated with CAD is still in an incipient stage needs to be explored further. The investigators attempt to quantify and compare the levels of micro-RNA 146a and micro-RNA 126 in subgingival as well as coronary plaque samples obtained from patients diagnosed with chronic periodontitis with and without coronary artery disease.
The role of micro-RNAs in chronic periodontitis associated with CAD is still in an incipient
stage needs to be explored further. The investigators attempt to quantify and compare the
levels of micro-RNA 146a and micro-RNA 126 in subgingival as well as coronary plaque samples
obtained from patients diagnosed with chronic periodontitis with and without coronary artery
disease.
Seventy-five participants were selected and grouped into 3 categories; 25 patients diagnosed
with chronic periodontitis and coronary artery disease: CP + CAD group; 25 patients diagnosed
with chronic periodontitis alone: CP group; and 25 systemically and periodontally healthy
controls (HP). Demographic variables, periodontal parameters, cardiac parameters, blood
pressure were obtained. miRNA-146a and miRNA126 levels were assessed in subgingival plaque
(SP) samples from all the three groups. Within CP+CAD group, SP samples of CP+CADa were
compared with coronary plaques samples (CP) of CP+CADb while the patient underwent CABG.
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