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Methadone clinical trials

View clinical trials related to Methadone.

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NCT ID: NCT06086171 Recruiting - Hip Fractures Clinical Trials

Perioperative Methadone Compared to Placebo in Elderly Hip Fracture Patients

Start date: November 10, 2023
Phase: Phase 4
Study type: Interventional

Hip fractures are associated with severe pain and are sustained by the elderly population. Demand for adequate pain relief combined with a low tolerance for analgesic drugs makes the treatment of elderly hip fracture patients difficult. Perioperative methadone could improve the analgesic treatment of these patients. An earlier pilot study showed that 0.10 mg/kg was safe to use. This study further investigates the advantages of methadone. The study's objective is to investigate the analgesic effects of a single dose of methadone given during hip fracture surgery.

NCT ID: NCT05985850 Not yet recruiting - Opioid Use Disorder Clinical Trials

Evaluating Tetrahydrocannabinol as an Adjunct to Opioid Agonist Therapy

THC-MMT
Start date: January 2024
Phase: Phase 2
Study type: Interventional

This pilot study will evaluate the feasibility and safety of using 1:1 tetrahydrocannabinol (THC):Cannabidiol (CBD) cannabis oil as an adjunct therapy to methadone-based Opioid Agonist Therapy (OAT) for individuals with opioid use disorder (OUD) in a community setting.

NCT ID: NCT05581901 Completed - Pain, Postoperative Clinical Trials

Perioperative Methadone in Hip Fracture Patients

Start date: January 12, 2023
Phase: Phase 4
Study type: Interventional

Postoperative analgesic treatment needs to be improved. Numerous studies suggest that a single dose of Methadone given during surgery significantly ameliorates postoperative pain and reduces postoperative opioid consumption. Perioperative methadone is already used in isolated cases such as patients with chronic pain or patients with high morphine tolerance. However, it is not routinely used in the elderly and fragile, and there is insufficient reliable evidence on this treatment and population. Further investigation is highly relevant and necessary.

NCT ID: NCT05459402 Recruiting - Chronic Pain Clinical Trials

Divided or Single Exposure (DOSE) Study

Start date: February 21, 2023
Phase: Phase 2
Study type: Interventional

This study will evaluate whether once versus twice daily dosing of methadone will be an effective method for managing comorbid pain and opioid use disorder.

NCT ID: NCT05075265 Not yet recruiting - Clinical trials for Cardiopulmonary Bypass

Pharmacokinetics of Methadone in Adults Undergoing Cardiac Surgery With Extracorporeal Circulation

Start date: October 2, 2021
Phase:
Study type: Observational

In cardiac surgery, the establishment of Cardiopulmonary bypass (CPB) involves profound changes that can alter the pharmacokinetics and clinical response to drugs. Methadone has characteristics that make it attractive for the management of postoperative pain, however, to date there are no pharmacokinetic or pharmacodynamic studies that allow guidance on how to perform the dosage and dose adjustment of methadone in patients undergoing cardiopulmonary bypass. The main of this study is to describe the pharmacokinetics of methadone in adult patients undergoing cardiac surgery with extracorporeal circulation. A pharmacokinetic clinical study will be proposed. Drug concentrations will be measured at different times, estimating how plasma levels vary before, during and after CPB. For the plasma methadone analysis, 10 blood samples will be taken from each patient following a pre-established schedule. They will be analyzed using a high performance liquid chromatography (HPLC) spectrofluorometric method. Changes in volumes, clearance, and other covariates associated with CPB are not expected to significantly affect methadone plasma concentrations.

NCT ID: NCT04764825 Recruiting - Pain, Postoperative Clinical Trials

Methadone for Spinal Fusion Surgery.

METASPINE
Start date: February 26, 2021
Phase: Phase 4
Study type: Interventional

A prospective double-blind, randomized controlled trial investigating the effect of a single-dose of intraoperative methadone in patients undergoing spinal fusion.

NCT ID: NCT04480554 Recruiting - Inflammation Clinical Trials

Anti-retroviral Therapy, Medications for Opioid Use Disorder, Opioids and HIV Infection - Study 1

AMOHI-1
Start date: January 30, 2023
Phase: Phase 2
Study type: Interventional

HIV infection, as well as exposure to opioids (including heroin), are associated with systemic immune activation including increased microbial translocation from the gut. The overall objective of this study is to define the impact of long-term mu-opiate receptor stimulation or blockage with medication for opiate use disorder (i.e, methadone, buprenorphine/naloxone, or extended-release naltrexone) on the kinetics and extent of immune reconstitution on HIV-1 infected people who inject opiate and initiating antiretroviral therapy.

NCT ID: NCT03948464 Terminated - Clinical trials for Opioid-Related Disorders

Slow-Release Oral Morphine for the Treatment of Opioid Use Disorder

pRESTO
Start date: December 6, 2019
Phase: Phase 3
Study type: Interventional

This is a non-inferiority randomized clinical trial that will compare slow release oral morphine vs methadone as a second line oral treatment for opioid use disorder.

NCT ID: NCT01870882 Completed - Addiction Clinical Trials

Attention Training for Opioid-maintained Cocaine Users

Start date: June 2013
Phase: Phase 4
Study type: Interventional

The purpose of this study is to determine the feasibility and preliminary efficacy of attention training using a portable electronic device for opioid-dependent cocaine-users stabilized on methadone.

NCT ID: NCT01270113 Completed - Methadone Clinical Trials

Improving Methadone Maintenance Treatment Compliance and Outcomes in China

Start date: n/a
Phase: N/A
Study type: Interventional

China faces the challenge of dual epidemics of drug use and HIV/AIDS. In responding to concerns of high rates of HIV/AIDS and other medical consequences among heroin users, China has recently implemented methadone maintenance treatment (MMT) programs nationwide. One problem noted with this rapid expansion is that the dropout rates from MMT have been high. The proposed study will adapt a motivational incentives (MI) intervention developed in the United States for use in Chinese MMT settings and will pilot test its effectiveness in improving treatment compliance and outcomes. The study's primary aims are: 1. to adapt a motivational incentives intervention in MMT in China, and 2. to experimentally pilot test the motivational incentives intervention. A secondary aim is to explore factors that may influence the outcomes of MMT that incorporates a motivational incentives intervention. It is hypothesized that the MI intervention can be adapted to Chinese settings and that it will optimize the positive outcomes of MMT in reducing HIV risks among heroin abusers. The collaborative team includes researchers in American and Chinese institutes (UCLA/Johns Hopkins/Washington, Shanghai Mental Health Center, Yunnan Institute for Drug Abuse), officials from national and local Chinese Centers for Disease Control and Prevention, and providers in local MMT clinics in Shanghai and Yunnan.